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Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors(Open Access)

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收录情况： ◇ ESCI

作者：
Lam, B.Y.K[a,b] * ; Leung, K.T[a] ; Yiu, B[a,b] ; Zhao, L[a,c] ; Biesbroek, J.M[d] ; Au, L[a,b] ; Tang, Y[a] ; Wang, K[e] ; Fan, Y[f] ; Fu, J.-H[g] ; Xu, Q[h] ; Song, H[i] ; Tian, X[j] ; Chu, W.C.W[k] ; Abrigo, J[k] ; Shi, L[c,k,l] ; Ko, H[a,b,m] ; Lau, A[a,b] ; Duering, M[n] ; Wong, A[a,b] ; Mok, V.C.T[a,b,o] ;
机构： [a]Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China [b]Therese Pei Fong Chow Research Center for Prevention of Dementia, Margaret Kam Ling Cheung Research Centre for Management of Parkinsonism, GeraldChoa Neuroscience Centre, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China [c]BrainNow Research Institute, Shenzhen, Guangdong Province, China [d]Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandseDepartment of Neurology, The First Hospital of Anhui Medical University, Hefei, Anhui Province, China [f]Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [g]Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China [h]Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China [i]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [j]Department of Neurology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin, China [k]Department of Imaging and Interventional Radiology, Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, HongKong SAR, China [l]Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China [m]Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China [n]Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany [o]Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
出处：
DOI： 10.1016/j.dadm.2019.09.003

关键词： Community subjects Diffusion tensor imaging Peak width of skeletonized mean diffusivity Processing speed Small vessel disease

摘要：
Introduction: Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age-related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods: We evaluated 801 stroke- and dementia-free elderlies with baseline and 3-year follow-up assessments. Regression analyses were used to assess the association between age-related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age-related cognitive outcomes. Results: PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3-year follow-up. The association between vascular risk factors and age-related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion: PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age-related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age-related cognitive alterations. © 2019 The Authors

基金：
This study was financially supported by the National Key Research and Development Program of China (grant number 2016YFC1300600 ), General Research Fund (grant number GRF CUHK 471911 ) and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Centre for Prevention of Dementia (in memory of Donald H. K. Chow).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
无
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
JCR分区：
出版当年[2017]版：
无
最新[2024]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版]

第一作者：
第一作者机构： [a]Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China [b]Therese Pei Fong Chow Research Center for Prevention of Dementia, Margaret Kam Ling Cheung Research Centre for Management of Parkinsonism, GeraldChoa Neuroscience Centre, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lam B.Y.K,Leung K.T,Yiu B,et al.Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors(Open Access)[J].ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING.2019,11(1):721-729.doi:10.1016/j.dadm.2019.09.003.
APA：
Lam, B.Y.K,Leung, K.T,Yiu, B,Zhao, L,Biesbroek, J.M...&Mok, V.C.T.(2019).Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors(Open Access).ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING,11,(1)
MLA：
Lam, B.Y.K,et al."Peak width of skeletonized mean diffusivity and its association with age-related cognitive alterations and vascular risk factors(Open Access)".ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING 11..1(2019):721-729

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