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The changes in the topological properties of brain structural network based on diffusion tensor imaging in pediatric epilepsy patients with vagus nerve stimulators: A graph theoretical analysis

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收录情况： ◇ SCIE

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机构： [1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Diffusion tensor imaging Generalized seizures Pediatric patients Topological properties Vagus nerve stimulation

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Purpose: This study aimed to analyze the topological characteristics of brain structural network in pediatric epilepsy patients with vagus nerve stimulation (VNS) by applying graph theoretical approaches. Methods: Nine patients with generalized seizures and eight normal controls (NC) were enrolled. Based on diffusion tensor imaging, graph theory analysis was used to characterize the topological properties in preoperative patients (EP-pre), postoperative patients (EP-post) and NC. The global properties included clustering coefficient (Cp), shortest path length (Lp), small-worldness (γ, λ, δ), global network efficiency (Eg) and local network efficiency (Eloc). The regional properties included degree centrality (DC), nodal efficiency (NE), nodal local efficiency (NLE) and nodal shortest path length (Np). Two sample t-test and paired sample t-test were utilized to compare properties difference. Results: All three groups followed small-world characteristics. There was no significant difference in small-worldness, Cp, Lp, Eg or Eloc between EP-pre and EP-post. Compared with EP-pre: DC in EP-post decreased in the right cuneus and right temporal gyri, while increased in the right paracentral lobule; NE in EP-post decreased in the left dorsolateral superior frontal gyrus, right cuneus, right supramarginal gyrus, and right rolandic operculum, while increased in the right paracentral lobule; NLE in EP-post decreased in the left posterior cingulate gyrus and right supramarginal gyrus, while increased in the left parahippocampal gyrus; NP in EP-post decreased in the right paracentral lobule, while increased in the right cuneus. Conclusion: VNS causes topological characteristics changes in pediatric patients with generalized seizures through regulating regional properties in some brain structures. © 2020 The Japanese Society of Child Neurology

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区临床神经病学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区儿科

JCR分区：

出版当年[2019]版：

Q4 CLINICAL NEUROLOGY

最新[2023]版：

Q2 PEDIATRICS Q3 PEDIATRICS Q3 CLINICAL NEUROLOGY Q4 CLINICAL NEUROLOGY

影响因子： 1.5 最新[2023版] 1.5 最新五年平均 1.504 出版当年[2019版] 1.491 出版当年五年平均 1.756 出版前一年[2018版] 1.961 出版后一年[2020版]

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第一作者机构： [1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [*1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing 100053, China.

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