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Hamartin: An Endogenous Neuroprotective Molecule Induced by Hypoxic Preconditioning

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收录情况： ◇ SCIE

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机构： [1]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, China, [3]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States, [4]Department of Neurosurgery, The Fifth Medical Centre of PLA General Hospital, Beijing, China, [5]Public Health Department, Biomedicine Research Center, Basic Medical College, Baotou, China, [6]Baotou Medical College of Neuroscience Institute, Baotou Medical College, Baotou, China

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关键词： hamartin ischemia hypoxia neuroprotection TSC1

摘要：

Hypoxic/ischemic preconditioning (HPC/IPC) is an innate neuroprotective mechanism in which a number of endogenous molecules are known to be involved. Tuberous sclerosis complex 1 (TSC1), also known as hamartin, is thought to be one such molecule. It is also known that hamartin is involved as a target in the rapamycin (mTOR) signaling pathway, which functions to integrate a variety of environmental triggers in order to exert control over cellular metabolism and homeostasis. Understanding the role of hamartin in ischemic/hypoxic neuroprotection will provide a novel target for the treatment of hypoxic-ischemic disease. Therefore, the proposed molecular mechanisms of this neuroprotective role and its preconditions are reviewed in this paper, with emphases on the mTOR pathway and the relationship between the expression of hamartin and DNA methylation.

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出版当年[2019]版：

大类 | 2 区生物

小类 | 3 区遗传学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区遗传学

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出版当年[2018]版：

Q2 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 2.8 最新[2023版] 3.3 最新五年平均 3.517 出版当年[2018版] 0 出版当年五年平均 4.151 出版前一年[2017版] 3.26 出版后一年[2019版]

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第一作者机构： [1]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, China,

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