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The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study(Open Access)

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收录情况： ◇ SCIE

作者：
Ling Sang[1] * ; Sibei Chen[1] * ; Xia Zheng[2] * ; Weijie Guan[1] * ; Zhihui Zhang[1] * ; Wenhua Liang[3] ; Ming Zhong[4] ; Li Jiang[5] ; Chun Pan[6] ; Wei Zhang[7] ; Jiaan Xia[8] ; Nanshan Chen[9] ; Wenjuan Wu[10] ; Hongkai Wu[11] ; Yonghao Xu[1] ; Xuesong Liu[1] ; Xiaoqing Liu[1] ; Jianxing He[3] ; Shiyue Li[1] ; Dingyu Zhang[12,13] ; Nanshan Zhong[1] ; Yimin Li[1] ;
机构： [1]Department of Pulmonary and Critical Care Medicine, State Key Laboratoryof Respiratory Diseases, Guangzhou Institute of Respiratory Health, The FirstAffiliated Hospital of Guangzhou Medical University, Guangzhou, China [2]Department of Critical Care Medicine, The First Affiliated Hospital ofZhejiang University, Zhejiang, Hangzhou, China [3]Department of ThoraxSurgery, State Key Laboratory of Respiratory Diseases, Guangzhou Institute ofRespiratory Health, The First Affiliated Hospital of Guangzhou MedicalUniversity, Guangzhou, China [4]Department of Critical Care Medicine,Zhongshan Hospital Fudan University, Shanghai, China [5]Department ofCritical Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing,China [6]Department of Critical Care Medicine, Zhongda Hospital, SoutheastUniversity, Nanjing, China [7]Emergency Department, the 900th Hospital ofJoint Service Corps of Chinese PLA, FuZhou, China [8]Department oftuberculosis, Wuhan Jinyintan Hospital, Wuhan, China [9]Department ofRespiratory and Critical Care Medicine, Wuhan Jinyintan Hospital, Wuhan,China [10]Department of Critical Care Medicine, Wuhan Jinyintan Hospital,Wuhan, China [11]State Key Laboratory of Respiratory Disease, National ClinicalResearch Center for Respiratory Disease, The First Affiliated Hospital ofGuangzhou Medical University, Guangzhou Medical University, Guangzhou,China [12]Research Center for Translational Medicine, Wuhan JinyintanHospital, Wuhan, China [13]Joint Laboratory of Infectious Diseases and Health,Wuhan Institute of Virology and Wuhan Jinyintan Hospital, Chinese Academyof Sciences, Wuhan, China
出处：
DOI： 10.1186/s12890-020-01305-5
ISSN：

关键词： Acute kidney injury Acute respiratory distres Coronavirus disease 2019 Intensive care unit Mechanical ventilation Syndrome

摘要：
Background: The clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear. Methods: We retrospectively reviewed medical records of all adult patients with laboratory-confirmed Covid-19 who were admitted to the intensive care unit (ICU) between January 23rd 2020 and April 6th 2020 at Wuhan JinYinTan Hospital and The First Affiliated Hospital of Guangzhou Medical University. Results: Among 210 patients, 131 were males (62.4%). The median Age was 64 years (IQR: 56–71). Of 92 (43.8%) patients who developed AKI during hospitalization, 13 (14.1%), 15 (16.3%) and 64 (69.6%) were classified as being at stage 1, 2 and 3, respectively. 54 patients (58.7%) received continuous renal replacement therapy. Age, sepsis, nephrotoxic drug, invasive mechanical ventilation and elevated baseline serum creatinine levels were associated with the occurrence of AKI. Renal recovery during hospitalization was identified among 16 patients with AKI (17.4%), who had a significantly shorter time from admission to AKI diagnosis, lower incidence of right heart failure and higher ratio of partial pressure of oxygen to the fraction of inspired oxygen. Of 210 patients, 93 deceased within 28 days of ICU admission. AKI stage 3, critical disease, greater Age and the lowest ratio of partial pressure of oxygen to the fraction of inspired oxygen being < 150 mmHg were independently associated with death. Conclusions: Among patients with Covid-19, the incidence of AKI was high. Our findings of the risk factors of the development of AKI and factors associated with renal function recovery may inform clinical management of patients with critical illness of Covid-19. © 2020, The Author(s).

基金：
The study was funded by National Science and Technology Major Project (No.2017ZX10204401003001), National Natural Science Foundation of China (No. 82070084), the Special Project of Guangdong Science and Technology Department (No. 2020B111105001), the Science and Technology Program of Guangzhou, China (No. 202008040003), the Major special projects of the Ministry of science and technology (No. 2020YFC0845100), the Major special projects of the Ministry of science and technology (No. 2020YFC0841300) and Natural Science Foundation of Guangdong Province, China (No.2020A1515011459). The funding body had no role in the study design, the collection, analysis or interpretation of the data. Acknowledgements
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 4 区 呼吸系统
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 呼吸系统
JCR分区：
出版当年[2018]版：
Q3 RESPIRATORY SYSTEM
最新[2023]版：
Q2 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, State Key Laboratoryof Respiratory Diseases, Guangzhou Institute of Respiratory Health, The FirstAffiliated Hospital of Guangzhou Medical University, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ling Sang,Sibei Chen,Xia Zheng,et al.The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study(Open Access)[J].BMC PULMONARY MEDICINE.2020,20(1):doi:10.1186/s12890-020-01305-5.
APA：
Ling Sang,Sibei Chen,Xia Zheng,Weijie Guan,Zhihui Zhang...&Yimin Li.(2020).The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study(Open Access).BMC PULMONARY MEDICINE,20,(1)
MLA：
Ling Sang,et al."The incidence, risk factors and prognosis of acute kidney injury in severe and critically ill patients with COVID-19 in mainland China: a retrospective study(Open Access)".BMC PULMONARY MEDICINE 20..1(2020)

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