机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[2]Department of Neurology, TianjinMedical University General Hospital, Tianjin, China,[3]Epilepsy Center, Beijing Fengtai You’anmen Hospital, Beijing, China,[4]Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China,[5]Advanced Center of Stroke, Beijing Institute for BrainDisorders, Beijing, China,[6]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital MedicalUniversity, Beijing, China,科技平台中美神经科学研究所首都医科大学宣武医院[7]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI,United States,[8]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科首都医科大学宣武医院
Cerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people's quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurological symptoms. This was one part of the prospective trial registered in (NCT03373292). A total of 37 CVOD patients were divided into the NBO group (5-8 L/min of oxygen inhalation, 1 h per time, 3 times daily, n = 19) and the control group (without oxygen inhalation, n = 18) randomly. The assessments were performed at admission, 1-week hospitalization, and 6-month follow-up. Quantitative electroencephalogram (qEEG) data were recorded prior to and post 1 h of NBO in some patients. R software was used for data analysis. No NBO-related adverse events were observed during the whole NBO intervention process. The 1-week Patient Global Impression of Change (PGIC) scale showed that the symptom improvement occurred in nine patients in the NBO group (47.4%) while none in the control group (p = 0.001). NBO could improve headache evaluated with visual analog scale (pre-NBO vs. post-NBO: 4.70 +/- 2.16 vs. 2.90 +/- 2.03, p = 0.024) and Headache Impact Test-6 (53.40 +/- 12.15 vs. 50.30 +/- 13.04, p = 0.041). As for 6-month PGIC follow-up, eight out of 14 cases (57.1%) in the NBO group reported improvement, while only one out of 12 patients in the control group replied mild improvement (p = 0.014). The qEEG revealed that NBO reduced the ratio of theta to alpha power (0.65 +/- 0.38 vs. 0.56 +/- 0.35, p = 0.030) over the fronto-central electrodes. To sum up, NBO may be a safe and effective approach to attenuate CVOD-related symptoms (especially for headache) by brain functional improvement resulting from increasing oxygen supply to the brain tissues.
基金:
National Key R&D Program of China [2017YFC1308401]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371289]; Project of Beijing Municipal Top Talent for Healthy Work of China [2014-2-015]
第一作者机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Neurology, TianjinMedical University General Hospital, Tianjin, China,
共同第一作者:
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推荐引用方式(GB/T 7714):
Ding Jiayue,Liu Yu,Li Xiangyu,et al.Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms[J].FRONTIERS IN NEUROLOGY.2020,11:599985.doi:10.3389/fneur.2020.599985.
APA:
Ding, Jiayue,Liu, Yu,Li, Xiangyu,Chen, Zhiying,Guan, Jingwei...&Meng, Ran.(2020).Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms.FRONTIERS IN NEUROLOGY,11,
MLA:
Ding, Jiayue,et al."Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms".FRONTIERS IN NEUROLOGY 11.(2020):599985