机构：[1]Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA[2]the Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学?脑血管病研究所首都医科大学宣武医院[3]the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background and Purpose-Normobaric oxygen (NBO) therapy may be neuroprotective in acute ischemic stroke. However, how NBO may affect intracerebral hemorrhage is unclear. We tested NBO in a rat model of striatal intracerebral hemorrhage. Methods-Intracerebral hemorrhage was induced by stereotactic injection of collagenase Type VII (0.5 U) into the right striatum of male Sprague-Dawley rats. One hour later, rats were randomized into controls (n = 13) versus NBO treatment (n = 13). NBO was applied for 2 hours. Hemorrhagic blood volume, brain water content, and neurological outcomes (forelimb placement test, forelimb asymmetry, neuroscore) were quantified at 72 hours. Experiments were repeated in a second independent laboratory to assess reproducibility in neurological outcomes (n = 10 per group). Results-NBO did not worsen hemorrhage severity or brain edema. There were no significant differences in hemorrhagic blood volumes (control, 6.4 +/- 0.9 mu L versus NBO, 7.0 +/- 2.1 mu L; P = 0.18) or brain water content (control, 81.9% +/- 1.1% versus NBO, 81.6% +/- 0.5%; P = 0.58). NBO did not affect any of the neurological outcome tests in the primary or secondary studies. Conclusions-NBO therapy may not worsen outcomes in intracerebral hemorrhage. (Stroke. 2011;42:1469-1472.)
基金：
National Institutes of Health grants P50- NS51343, R01-NS51412, and R01-NS56458.
第一作者机构：[1]Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
通讯作者：
通讯机构：[3]the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
推荐引用方式(GB/T 7714)：
Norio Fujiwara ,Emiri T. Mandeville,Xiaokun Geng,et al.Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage[J].STROKE.2011,42(5):1469-1472.doi:10.1161/STROKEAHA.110.593350.
APA：
Norio Fujiwara,,Emiri T. Mandeville,Xiaokun Geng,Yumin Luo,Ken Arai...&Eng H. Lo.(2011).Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage.STROKE,42,(5)
MLA：
Norio Fujiwara,,et al."Effect of Normobaric Oxygen Therapy in a Rat Model of Intracerebral Hemorrhage".STROKE 42..5(2011):1469-1472
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