机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院国家老年疾病临床医学研究中心科技平台[2]Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, School of Communication and Information Technology, Shanghai University, Shanghai, China,[3]Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China,[4]Institute of Biomedical Engineering, Shanghai University, Shanghai, China,[5]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[6]National Clinical Research Center for Geriatric Disorders, Beijing, China
The aim of this study was to determine a pattern associated with longitudinal changes of beta-amyloid (A beta) deposition during cognitively normal(CN) healthy aging. We used F-18-florbetapir (AV-45) PET images of the brains of 207 cognitively normal subjects (CN1), obtained through the Alzheimer's Disease Neuroimaging Initiative (ADNI), to identify the healthy aging pattern and 76 cognitively normal healthy subjects (CN2), obtained through the Xuanwu Hospital of Capital Medical University, Beijing, China, to verify it. A voxel-based correlation analysis of standardized uptake value ratio (SUVR) map image and age was conducted using the DPABI (Data Processing & Analysis of Brain Imaging) software to identify the pattern. The sum of squares due to errors (SSE), R-square (R-2) and the root-mean-square error (RMSE) were calculated to assess the quality of curve fitting. Among them, R-2 was proposed as the coherence coefficient, which was as an index to assess the correlation between SUVR value of the pattern and subjects' age. The pattern characterized by age-associated longitudinal changes of A beta deposition was mainly distributed in the right middle and inferior temporal gyrus, the right temporal pole: middle temporal gyrus, the right inferior occipital gyrus, the right inferior frontal gyrus (triangular portion), and the right precentral gyrus. There were a significant positive correlation between the SUVR value of the pattern and age for each CN group (CN1: R-2 = 0.120, p < 0.001 for quadratic model; CN2: R-2 = 0.152, p = 0.002 for quadratic model). These findings suggest a pattern of changes in A beta deposition that can be used to distinguish physiological changes from pathophysiological changes, constituting a new method for elucidating the neuropathological mechanism of Alzheimer's disease.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61633018, 82020108013, 61603236, 81830059]; National Key Research and Development Program of China [2016YFC1306300, 2018YFC1312000, 2018YFC1707704]; 111 ProjectMinistry of Education, China - 111 Project [D20031]; Shanghai Municipal Science and Technology Major Project [2017SHZDZX01]; Beijing Municipal Commission of Health and Family Planning [PXM2020_026283_000002]; Alzheimer's Disease Neuroimaging Initiative (ADNI): the National Institutes of Health [U01 AG024904]; Department of DefenseUnited States Department of Defense [W81XWH-12-2-0012]; National Institute of AgingUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA); National Institute of Biomedical Imaging and BioengineeringUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB); AbbVie; Alzheimer's AssociationAlzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica Inc.; BiogenBiogen; Bristol-Myers Squibb CompanyBristol-Myers Squibb; CereSpir Inc.; Eisai Inc.Eisai Co Ltd; Elan Pharmaceuticals Inc.; Eli Lilly and CompanyEli Lilly; EuroImmun; F. Hoffmann-La Roche Ltd.Hoffmann-La Roche; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR)
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,[2]Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication, School of Communication and Information Technology, Shanghai University, Shanghai, China,[3]Shanghai Institute for Advanced Communication and Data Science, Shanghai University, Shanghai, China,[4]Institute of Biomedical Engineering, Shanghai University, Shanghai, China,[5]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[6]National Clinical Research Center for Geriatric Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Xie Yunyan,Yang Qin,Liu Chunhua,et al.Exploring the Pattern Associated With Longitudinal Changes of beta-Amyloid Deposition During Cognitively Normal Healthy Aging[J].FRONTIERS IN MEDICINE.2021,7:doi:10.3389/fmed.2020.617173.
APA：
Xie, Yunyan,Yang, Qin,Liu, Chunhua,Zhang, Qi,Jiang, Jiehui...&the Alzheimer’s Disease Neuroimaging Initiative.(2021).Exploring the Pattern Associated With Longitudinal Changes of beta-Amyloid Deposition During Cognitively Normal Healthy Aging.FRONTIERS IN MEDICINE,7,
MLA：
Xie, Yunyan,et al."Exploring the Pattern Associated With Longitudinal Changes of beta-Amyloid Deposition During Cognitively Normal Healthy Aging".FRONTIERS IN MEDICINE 7.(2021)
