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Identification of genes and pathways involved in malignant pleural mesothelioma using bioinformatics methods(Open Access)

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收录情况： ◇ SCIE

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机构： [1]Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China

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关键词： Bioinformatics Cancer Differentially expressed genes Gene expression profile Microarray Protein–protein interaction

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Background: Malignant pleural mesothelioma (MPM) is a rare tumor in the pleura. This study was carried out to identify key genes and pathways that may be involved in MPM. Methods: Microarray datasets GSE51024 and GSE2549 were analyzed for differentially expressed genes (DEGs) between normal and MPM tissues. The identified DEGs were subjected to functional analyses using bioinformatics tools. Results: A total of 276 DEGs were identified, consisting of 187 downregulated and 79 upregulated genes. Gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analysis indicated that the DEGs were enriched in extracellular structure organization, extracellular matrix, and ECM−receptor interaction. Due to high degree of connectivity among 24 hub genes, EZH2 and HMMR are likely to play roles in the carcinogenesis and progression of MPM. The two genes were found over-expressed in MPM tissues. Patients with elevated EZH2 and HMMR expressions had poor overall survival. Conclusions: EZH2 and HMMR are identified to be the hub genes for MPM and they may be further characterized to better understand the molecular mechanisms underlying the carcinogenesis of MPM. © 2021, The Author(s).

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区遗传学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区遗传学

JCR分区：

出版当年[2019]版：

Q3 GENETICS & HEREDITY

最新[2023]版：

Q3 GENETICS & HEREDITY

影响因子： 2.1 最新[2023版] 2.5 最新五年平均 2.57 出版当年[2019版] 3.193 出版当年五年平均 2.568 出版前一年[2018版] 3.063 出版后一年[2020版]

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第一作者机构： [1]Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China

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