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Case Report: Anti-N-Methyl-D-Aspartate Receptor Encephalitis in an Elderly Patient With Primary Sjogren's Syndrome

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机构: [1]Department of Rheumatology and Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
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关键词: primary Sjogren's syndrome autoimmune encephalitis anti-N-methyl-D- aspartate receptor cognitive dysfunction Alzheimer's disease

摘要:
Neurological manifestations of primary Sjogren's syndrome (SS) are diverse involving the peripheral and central nervous system. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, as the most prevalent autoimmune encephalitis, was rarely reported to be complicated with primary SS. Herein, we present an elderly patient with a 15-year history of primary SS presenting with progressive cognitive dysfunction due to anti-NMDAR encephalitis that was once misdiagnosed as primary degenerative dementia. Early recognition of anti-NMDAR encephalitis and initiation of treatment with steroids and immunosuppressant gained a favorable outcome. Our findings enhance the awareness that autoimmune encephalitis should be taken into account in the patients with primary SS presenting with progressive cognitive impairment.

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出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
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出版当年[2019]版:
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES
最新[2023]版:
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

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第一作者机构: [1]Department of Rheumatology and Allergy, Xuanwu Hospital, Capital Medical University, Beijing, China,
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