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Single-nucleus transcriptomic landscape of primate hippocampal aging

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Hui Zhang[1,6] * ; Jiaming Li[4,6,7,10,11] * ; Jie Ren[4,5,6,7,10] * ; Shuhui Sun[1,5,13] ; Shuai Ma[1,5,13] ; Weiqi Zhang[4,5,6,7,10] ; Yang Yu[12,14] ; Yusheng Cai[1,5,13] ; Kaowen Yan[1,5,13] ; Wei Li[2,5,6,13] ; Baoyang Hu[2,5,6,13] ; Piu Chan[3] ; Guo-Guang Zhao[3,9] ; Juan Carlos Izpisua Belmonte[15] ; Qi Zhou[2,5,6,13] ; Jing Qu[2,5,6,13] ; Si Wang[3,8] ; Guang-Hui Liu[1,3,5,6,13] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [4]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China [5]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [7]China National Center for Bioinformation, Beijing 100101, China [8]Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [9]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [10]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China [11]Sino-Danish Center for Education and Research, Beijing 101408, China [12]Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China [13]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [14]Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, China [15]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA
出处：
DOI： 10.1007/s13238-021-00852-9
ISSN：

关键词： aging hippocampus primate single-cell RNA sequencing

摘要：
The hippocampus plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases. Yet a systematic profiling of the aging effects on various hippocampal cell types in primates is still missing. Here, we reported a variety of new aging-associated phenotypic changes of the primate hippocampus. These include, in particular, increased DNA damage and heterochromatin erosion with time, alongside loss of proteostasis and elevated inflammation. To understand their cellular and molecular causes, we established the first single-nucleus transcriptomic atlas of primate hippocampal aging. Among the 12 identified cell types, neural transiently amplifying progenitor cell (TAPC) and microglia were most affected by aging. In-depth dissection of gene-expression dynamics revealed impaired TAPC division and compromised neuronal function along the neurogenesis trajectory; additionally elevated pro-inflammatory responses in the aged microglia and oligodendrocyte, as well as dysregulated coagulation pathways in the aged endothelial cells may contribute to a hostile microenvironment for neurogenesis. This rich resource for understanding primate hippocampal aging may provide potential diagnostic biomarkers and therapeutic interventions against age-related neurodegenerative diseases.

基金：
This work was supported by the National Key Research and Development Program of China (2020YFA0804000), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010000), the National Key Research and Development Program of China (2019YFA0110100, 2020YFA0112201, 2018YFC2000100, 2017YFA0103304, 2017YFA0102802, 2018Y FA0107203, 2020YFA0803401, and 2019YFA0802202), the National Natural Science Foundation of China (Grant Nos. 81921006, 81625009, 91749202, 81861168034, 91949209, 92049304, 81822018, 82071588, 92049116, 31900523, 32000500, 31970597, 82030037, and 81801534), the Program of the Beijing Municipal Science and Technology Commission (Z191100001519005), Beijing Natural Science Foundation (Z190019), the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-221), K. C. Wong Education Foundation (GJTD-2019-06, GJTD-2019-08), the International Partnership Program of Chinese Academy of Sciences (152111KYSB20160004), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2020-JKCS-011), the State Key Laboratory of Stem Cell and Reproductive Biology, the State Key Laboratory of Membrane Biology, the Milky Way Research Foundation (MWRF), and the Moxie Foundation (for J.C.I.B.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 生物
小类 | 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2019]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China [5]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [8]Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [13]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
推荐引用方式(GB/T 7714)：
Hui Zhang,Jiaming Li,Jie Ren,et al.Single-nucleus transcriptomic landscape of primate hippocampal aging[J].PROTEIN & CELL.2021,12(9):695-716.doi:10.1007/s13238-021-00852-9.
APA：
Hui Zhang,Jiaming Li,Jie Ren,Shuhui Sun,Shuai Ma...&Guang-Hui Liu.(2021).Single-nucleus transcriptomic landscape of primate hippocampal aging.PROTEIN & CELL,12,(9)
MLA：
Hui Zhang,et al."Single-nucleus transcriptomic landscape of primate hippocampal aging".PROTEIN & CELL 12..9(2021):695-716

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