机构：[a]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[b]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China[c]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China
The global race-dependent association of Alzheimer's disease (AD) and apolipoprotein E (APOE) genotype is not well understood. Transethnic analysis of APOE could clarify the role of genetics in AD risk across populations.This study aims to determine how race and APOE genotype affect the risks for AD.We performed a systematic search of PubMed, Embase, Web of Science, and the Cochrane Library since 1993 to Aug 25, 2020. A total of 10,395 reports were identified, and 133 were eligible for analysis with data on 77,402 participants. Studies contained AD clinical diagnostic and APOE genotype data. Homogeneous data sets were pooled in case-control analyses. Odds ratios and 95% confidence intervals for developing AD were calculated for populations of different races and APOE genotypes.The proportion of APOE genotypes and alleles differed between populations of different races. Results showed that APOEɛ4 was a risk factor for AD, whereas APOEɛ2 protected against it. The effects of APOEɛ4 and ɛ2 on AD risk were distinct in various races, they were substantially attenuated among Black people. Sub-group analysis found a higher frequency of APOEɛ4/ɛ4 and lower frequency of APOEɛ3/ɛ3 among early-onset AD than late-onset AD in a combined group and different races.Our meta-analysis suggests that the association of APOE genotypes and AD differ between races. These results enhance our understanding of APOE-related risk for AD across race backgrounds and provide new insights into precision medicine for AD.
基金：
This study was supported by the Key Project
of the National Natural Science Foundation of
China (81530036, U20A20354); Beijing Natural
Science Foundation (7192077); National Key
R&D Program of China (2017YFC1310100,
2016YFC1306305); the National Key Scientific
Instrument and Equipment Development Project
(31627803); Beijing Municipal Science & Tech-
nology Commission (Z181100001718110); Beijing
Scholars Program; Beijing Brain Initiative from Bei-
jing Municipal Science & Technology Commission
(Z201100005520016, Z201100005520017).
第一作者机构：[a]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[a]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China[c]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[*1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun St, Beijing, China.
推荐引用方式(GB/T 7714)：
Wei Qin,Wenwen Li,Qi Wang,et al.Race-Related Association between APOE Genotype and Alzheimer's Disease: A Systematic Review and Meta-Analysis.[J].JOURNAL OF ALZHEIMERS DISEASE.2021,83(2):897-906.doi:10.3233/JAD-210549.
APA：
Wei Qin,Wenwen Li,Qi Wang,Min Gong,Tingting Li...&Jianping Jia.(2021).Race-Related Association between APOE Genotype and Alzheimer's Disease: A Systematic Review and Meta-Analysis..JOURNAL OF ALZHEIMERS DISEASE,83,(2)
MLA：
Wei Qin,et al."Race-Related Association between APOE Genotype and Alzheimer's Disease: A Systematic Review and Meta-Analysis.".JOURNAL OF ALZHEIMERS DISEASE 83..2(2021):897-906
