机构：[1]Department of Cardiology, Hospital of The University of Electronic Science & Technology of China & Sichuan Provincial People’s Hospital, Chengdu 610072, China非手术科室心内科四川省人民医院[2]Department of Cardiovascular Surgery, The Seventh People’s Hospital of Chengdu, Chengdu 610021, China[3]Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China[4]Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China[5]Department of Cardiovascular Surgery Center, Beijing An-zhen Hospital, Capital Medical University, Beijing 100029, China临床科室心脏外科中心血管科首都医科大学附属安贞医院
Aim: Conotruncal heart defects (CTDs) are the most common form of congenital heart disease. We investigated the association of these two single-nucleotide polymorphisms (SNPs) in the promoter of miR-143/145 (rs353292 and rs4705343) with the susceptibility to CTDs in a Chinese population. Materials & methods: Two SNPs in the promoter of miR-143/145 (rs353292 and rs4705343) have been examined by PCR-RFLP methodology for 259 CTDs patients and 303 control subjects. Results: An association between SNP rs4705343 of miR-143/145 and CTDs has been confirmed in the Chinese Han population. Conclusion: Our results indicated that SNP rs4705343 in miR-143/145 is a potential genetic marker for CTDs in the Chinese Han population.
基金：
This work was supported by Doctoral Foundation of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital
(grant number 830305030829), Scientific Research Foundation for the Returned Overseas Chinese Scholars of Sichuan Province
(grant number 2016064) and the National Natural Science Foundation of China (grant number 81600259).
第一作者机构：[1]Department of Cardiology, Hospital of The University of Electronic Science & Technology of China & Sichuan Provincial People’s Hospital, Chengdu 610072, China
通讯作者：
通讯机构：[1]Department of Cardiology, Hospital of The University of Electronic Science & Technology of China & Sichuan Provincial People’s Hospital, Chengdu 610072, China
推荐引用方式(GB/T 7714)：
Wen Heling,Zhang Rui,Li Yajiao,et al.Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects.[J].PERSONALIZED MEDICINE.2019,16(6):449-455.doi:10.2217/pme-2018-0154.
APA：
Wen Heling,Zhang Rui,Li Yajiao,Qian Hong,Yan Zhiguo...&Li Gang.(2019).Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects..PERSONALIZED MEDICINE,16,(6)
MLA：
Wen Heling,et al."Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects.".PERSONALIZED MEDICINE 16..6(2019):449-455
