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Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Qian Zhao[1,2] * ; Yandong Zheng[3,4] * ; Dongxin Zhao[11] * ; Liyun Zhao[1,2] ; Lingling Geng[1,2] ; Shuai Ma[5,6,7] ; Yusheng Cai[5,6,7] ; Chengyu Liu[3,4] ; Yupeng Yan[5,6,7] ; Juan Carlos Izpisua Belmonte[12] ; Si Wang[1,2,10] ; Weiqi Zhang[4,6,7,8,9] ; Guang-Hui Liu[1,2,4,5,6,7] ; Jing Qu[3,4,6,7] ;
机构： [1]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital MedicalUniversity, Beijing 100053, China [2]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuan Wu Hospital, CapitalMedical University, Beijing 100053, China [3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]University of Chinese Academy of Sciences, Beijing 100049, China [5]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation,Beijing 100101, China [9]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China [10]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China [11]Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China [12]Altos Labs, Inc., San Diego, CA 94022, USA
出处：
DOI： 10.1093/procel/pwac062
ISSN：

关键词： single-cell RNA-sequencing Que hair follicle regeneration endothelial cells HIF-1 alpha

摘要：
Hair loss affects millions of people at some time in their life, and safe and efficient treatments for hair loss are a significant unmet medical need. We report that topical delivery of quercetin (Que) stimulates resting hair follicles to grow with rapid follicular keratinocyte proliferation and replenishes perifollicular microvasculature in mice. We construct dynamic single-cell transcriptome landscape over the course of hair regrowth and find that Que treatment stimulates the differentiation trajectory in the hair follicles and induces an angiogenic signature in dermal endothelial cells by activating HIF-1 alpha in endothelial cells. Skin administration of a HIF-1 alpha agonist partially recapitulates the pro-angiogenesis and hair-growing effects of Que. Together, these findings provide a molecular understanding for the efficacy of Que in hair regrowth, which underscores the translational potential of targeting the hair follicle niche as a strategy for regenerative medicine, and suggest a route of pharmacological intervention that may promote hair regrowth.

基金：
National Key Research and Development Program of China [2020YFA0804000]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16000000]; National Natural [81861168034, 82271600, 82201727]; National Key Research and Development Program of China [2018YFC2000100, 2018YFA0107203, 2020YFA0112200, 2021YFF1201005, 2021ZD0202401, 2022YFA1103700, 2021YFA1101401]; CAS Project for Young Scientists in Basic Research [YSBR-076, YSBR-012]; Program of the Beijing Natural Science Foundation [Z190019]; K. C. Wong Education Foundation [GJTD-2019-06, GJTD-2019-08]; Tencent Foundation [2021-1045]; Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes [11000022T000000461062]; Youth Innovation Promotion Association of CAS [E1CAZW0401, 2022083]; Young Elite Scientists Sponsorship Program by CAST [YESS20200012, YESS20210002]; Informatization Plan of Chinese Academy of Sciences [CAS-WX2021SF-0301, CAS-WX2022SDC-XK14, CAS-WX2021SF-0101]; Beijing Hospitals Authority Youth Programme [QML20200802]; Open Research Program of State Key Laboratory of Membrane Biology [2021KF02]; Key Laboratory of Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education [2021-A-001]

基金编号： 2020YFA0804000 XDA16000000 81861168034 82271600 82201727 2018YFC2000100 2018YFA0107203 2020YFA0112200 2021YFF1201005 2021ZD0202401 2022YFA1103700 2021YFA1101401 YSBR-076 YSBR-012 Z190019 GJTD-2019-06 GJTD-2019-08 2021-1045 11000022T000000461062 E1CAZW0401 2022083 YESS20200012 YESS20210002 CAS-WX2021SF-0301 CAS-WX2022SDC-XK14 CAS-WX2021SF-0101 QML20200802 2021KF02 2021-A-001

语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital MedicalUniversity, Beijing 100053, China [2]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuan Wu Hospital, CapitalMedical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital MedicalUniversity, Beijing 100053, China [2]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuan Wu Hospital, CapitalMedical University, Beijing 100053, China [3]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]University of Chinese Academy of Sciences, Beijing 100049, China [5]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [6]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation,Beijing 100101, China [9]Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China [10]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
推荐引用方式(GB/T 7714)：
Qian Zhao,Yandong Zheng,Dongxin Zhao,et al.Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration[J].PROTEIN & CELL.2023,14(6):398-415.doi:10.1093/procel/pwac062.
APA：
Qian Zhao,Yandong Zheng,Dongxin Zhao,Liyun Zhao,Lingling Geng...&Jing Qu.(2023).Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration.PROTEIN & CELL,14,(6)
MLA：
Qian Zhao,et al."Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration".PROTEIN & CELL 14..6(2023):398-415

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