个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：梯队期刊

作者：
Jing, Ying[1,4] * ; Zuo, Yuesheng[4,6,8] * ; Yu, Yang[10,12] * ; Sun, Liang[11] * ; Yu, Zhengrong[13] * ; Ma, Shuai[2,5,7] ; Zhao, Qian[3,9] ; Sun, Guoqiang[1] ; Hu, Huifang[2,5] ; Li, Jingyi[2,5,7] ; Huang, Daoyuan[3] ; Liu, Lixiao[4,6,8] ; Li, Jiaming[4,6,8,14] ; Xin, Zijuan[2,5] ; Huang, Haoyan[3,9] ; Belmonte, Juan Carlos Izpisua[16] ; Zhang, Weiqi[4,5,6,8,15] ; Wang, Si[3,7,9,17] ; Qu, Jing[1,4,5,7,14] ; Liu, Guang-Hui[2,3,4,5,7] ;
机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China [2]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China [3]Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China [4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [5]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [6]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [7]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [8]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [9]Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc,Beijing Municipal Geriatr Med, Beijing 100053, Peoples R China [10]Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing 100191, Peoples R China [11]Chinese Acad Med Sci, Beijing Hosp, Beijing Inst Geriatr, Inst Geriatr Med,Natl Ctr Gerontol Natl Hlth Commi, Beijing 100730, Peoples R China [12]Peking Univ Third Hosp, Clin Stem Cell Res Ctr, Beijing 100191, Peoples R China [13]Peking Univ First Hosp, Dept Orthopaed, Beijing 100034, Peoples R China [14]Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China [15]Sino Danish Ctr Educ & Res, Beijing 101408, Peoples R China [16]Altos Labs Inc, San Diego, CA 94022 USA [17]Fifth Peoples Hosp Chongqing, Chongqing 400062, Peoples R China
出处：
DOI： 10.1093/procel/pwac061
ISSN：

关键词： single-nucleus RNA sequencing primate aging skeletal muscle FOXO3

摘要：
Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and increases the risk of many aging-related metabolic diseases. Here, we report phenotypic and single-nucleus transcriptomic analyses of non-human primate skeletal muscle aging. A higher transcriptional fluctuation was observed in myonuclei relative to other interstitial cell types, indicating a higher susceptibility of skeletal muscle fiber to aging. We found a downregulation of FOXO3 in aged primate skeletal muscle, and identified FOXO3 as a hub transcription factor maintaining skeletal muscle homeostasis. Through the establishment of a complementary experimental pipeline based on a human pluripotent stem cell-derived myotube model, we revealed that silence of FOXO3 accelerates human myotube senescence, whereas genetic activation of endogenous FOXO3 alleviates human myotube aging. Altogether, based on a combination of monkey skeletal muscle and human myotube aging research models, we unraveled the pivotal role of the FOXO3 in safeguarding primate skeletal muscle from aging, providing a comprehensive resource for the development of clinical diagnosis and targeted therapeutic interventions against human skeletal muscle aging and the onset of sarcopenia along with aging-related disorders.

基金：
Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16000000]; National Natural Science Foundation of China [82071588, 81921006, 82125011, 92149301, 92168201, 92049116, 32121001, 82192863, 91949209, 92049304, 82122024, 82001477, 31900523, 81861168034, 32000500, 82271600, 82201714]; National Key Research and Development Program of China [2018YFC2000100, 2020YFA0804000, 2018YFA0107203, 2020YFA0112200, 2021YFF1201005, 2021ZD0202401, 2018YFC2000400, 2020YFA0113400, 2021YFE0111800, 2022YFA1103700]; Program of the Beijing Natural Science Foundation [Z190019]; K. C. Wong Education Foundation [GJTD-2019-06, GJTD-2019-08]; Beijing Medical Research [2021-8]; Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes [11000022T000000461062]; Young Elite Scientists Sponsorship Program by CAST [YESS20200012, YESS20210002]; CAS Project for Young Scientists in Basic Research [YSBR-076, YSBR-012, YSBR-036]; Youth Innovation Promotion Association of CAS [E1CAZW0401, 2020085, 2022083]; Informatization Plan of Chinese Academy of Sciences [CAS-WX2022SDC-XK14, CAS-WX2021SF-0301, CAS-WX2021SF-0101]; Tencent Foundation [2021-1045]; CAMS Innovation Fund for Medical Sciences [2021-I2M-1-050]; Fellowship of China Postdoctoral Science Foundation [2022M712216]

基金编号： XDA16000000 82071588 81921006 82125011 92149301 92168201 92049116 32121001 82192863 91949209 92049304 82122024 82001477 31900523 81861168034 32000500 82271600 82201714 2018YFC2000100 2020YFA0804000 2018YFA0107203 2020YFA0112200 2021YFF1201005 2021ZD0202401 2018YFC2000400 2020YFA0113400 2021YFE0111800 2022YFA1103700 Z190019 GJTD-2019-06 GJTD-2019-08 2021-8 11000022T000000461062 YESS20200012 YESS20210002 YSBR-076 YSBR-012 YSBR-036 E1CAZW0401 2020085 2022083 CAS-WX2022SDC-XK14 CAS-WX2021SF-0301 CAS-WX2021SF-0101 2021-1045 2021-I2M-1-050 2022M712216

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China [4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China
共同第一作者：
通讯作者：
通讯机构： [1]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China [2]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China [3]Capital Med Univ, Xuanwu Hosp, Adv Innovat Ctr Human Brain Protect, Natl Clin Res Ctr Geriatr Disorders, Beijing 100053, Peoples R China [4]Univ Chinese Acad Sci, Beijing 100049, Peoples R China [5]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China [6]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China [7]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China [8]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China [9]Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc,Beijing Municipal Geriatr Med, Beijing 100053, Peoples R China [14]Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China [15]Sino Danish Ctr Educ & Res, Beijing 101408, Peoples R China [17]Fifth Peoples Hosp Chongqing, Chongqing 400062, Peoples R China
推荐引用方式(GB/T 7714)：
Jing Ying,Zuo Yuesheng,Yu Yang,et al.Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging[J].PROTEIN & CELL.2023,14(7):499-514.doi:10.1093/procel/pwac061.
APA：
Jing, Ying,Zuo, Yuesheng,Yu, Yang,Sun, Liang,Yu, Zhengrong...&Liu, Guang-Hui.(2023).Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging.PROTEIN & CELL,14,(7)
MLA：
Jing, Ying,et al."Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging".PROTEIN & CELL 14..7(2023):499-514

相关文献

[1]Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging [2]Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging [3]A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes [4]A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis [5]Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. [6]SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing [7]Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling [8]Glutathione restoration: a sword to combat skeletal muscle stem cell aging [9]Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsy [10]Skeletal Muscle Metabolic Alternation Develops Sarcopenia

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院