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New insights into the roles of oligodendrocytes regulation in ischemic stroke recovery

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China [4]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [5]Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [6]Department of Neurosurgery, Wayne State University, Detroit, MI, USA [7]Beijing Institute of Brain Disorders, Capital Medical University, 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China.

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关键词： Oligodendrocytes Ischemic stroke White matter injury Remyelination Therapy

摘要：

Oligodendrocytes (OLs), the myelin-forming cells of the central nervous system, are integral to axonal integrity and function. Hypoxia-ischemia episodes can cause severe damage to these vulnerable cells through excitotoxicity, oxidative stress, inflammation, and mitochondrial dysfunction, leading to axonal dystrophy, neuronal dysfunction, and neurological impairments. OLs damage can result in demyelination and myelination disorders, severely impacting axonal function, structure, metabolism, and survival. Adult-onset stroke, periventricular leukomalacia, and post-stroke cognitive impairment primarily target OLs, making them a critical therapeutic target. Therapeutic strategies targeting OLs, myelin, and their receptors should be given more emphasis to attenuate ischemia injury and establish functional recovery after stroke. This review summarizes recent advances on the function of OLs in ischemic injury, as well as the present and emerging principles that serve as the foundation for protective strategies against OLs deaths.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 1 区

医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 2 区

医学

小类 | 2 区神经科学

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出版当年[2021]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.1 最新[2023版] 5.6 最新五年平均 7.046 出版当年[2021版] 6.846 出版当年五年平均 5.996 出版前一年[2020版] 6.1 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China

通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China [3]Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China [4]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China [7]Beijing Institute of Brain Disorders, Capital Medical University, 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China. [*1]Department of Emergency, Xuanwu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing 100053, China

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