机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, China[2]The Institute of Neuroscience, Soochow University, Suzhou City, China[3]Department of Neurology, Suzhou Kowloon Hospital, Suzhou City, China
White matter tracts are composed of axons and myelinating oligodendrocytes. Oligodendrocytes are the myelinating cells in the central nervous system that allow formation of myelin and saltatory nerve conduction. Cerebral white matter is highly vulnerable to ischemic injury in adults and neonates. White matter injury in newborn brains results in cerebral palsy and cognitive disability. In this study, we found that XAV939, a small-molecular inhibitor that stimulated beta-catenin degradation by stabilizing axin, protected against serum and glucose deprivation (SGD)-induced cell death in oligodentrocyte cell line OLN-93 cells in a concentration-dependent manner. We further showed that XAV939 reduced caspase-3 and caspase-8 levels and increased the expression of phosphorylated Akt in SGD-induced OLN-93 cells. Our data demonstrate that XAV939 protects against neonatal hypoxic/ ischemic injury. In summary, our results demonstrate that XAV939 confers neuroprotection against SGD-induced injury in OLN-93 cells via its antiapoptotic activity and the loss of oligodendrocytes and neurons in neonatal hypoxic/ischemic injury. (C) 2014 Wiley Periodicals, Inc.
基金：
Contract grant sponsor: National Natural Science Foundation of China;
Contract grant number: 81301011
第一作者机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, China[2]The Institute of Neuroscience, Soochow University, Suzhou City, China
共同第一作者：
通讯作者：
通讯机构：[*]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province 215004, China
推荐引用方式(GB/T 7714)：
Jing Chen ,Jizhen Li ,Zhigang Miao ,et al.XAV939, a Small Molecular Inhibitor, Provides Neuroprotective Effects on Oligodentrocytes[J].JOURNAL OF NEUROSCIENCE RESEARCH.2014,92(10):1252-8.doi:10.1002/jnr.23415.
APA：
Jing Chen,,Jizhen Li,,Zhigang Miao,,Xingshun Xu,&Chun-Feng Liu.(2014).XAV939, a Small Molecular Inhibitor, Provides Neuroprotective Effects on Oligodentrocytes.JOURNAL OF NEUROSCIENCE RESEARCH,92,(10)
MLA：
Jing Chen,,et al."XAV939, a Small Molecular Inhibitor, Provides Neuroprotective Effects on Oligodentrocytes".JOURNAL OF NEUROSCIENCE RESEARCH 92..10(2014):1252-8
