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DNA damage response, a double-edged sword for vascular aging

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收录情况： ◇ SCIE

作者：
Zhang Xiao[1,2,3] * ; Zhao Qing[4] * ; Wang Tao[2,3] * ; Long Qilin[1] ; Sun Yixin[5] ; Jiao Liqun[2,3,6,*1] ; Gullerova Monika[1,*2] ;
机构： [1]Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]China International Neuroscience Institute (China-INI), Beijing 100053, China [4]M.D. Program, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [5]First Hospital, Peking University, Beijing, China [6]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
出处：
DOI： 10.1016/j.arr.2023.102137
ISSN：

关键词： DNA damage response Vascular aging Deficiency Overactivation Potential therapy

摘要：
Vascular aging is a major risk factor for age-related cardiovascular diseases, which have high rates of morbidity and mortality. It is characterized by changes in the blood vessels, such as macroscopically increased vascular diameter and intima-medial thickness, chronic inflammation, vascular calcification, arterial stiffening, and atherosclerosis. DNA damage and the subsequent various DNA damage response (DDR) pathways are important causative factors of vascular aging. Deficient DDR, which may result in the accumulation of unrepaired damaged DNA or mutations, can lead to vascular aging. On the other hand, over-activation of some DDR proteins, such as poly (ADP ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM), also can enhance the process of vascular aging, suggesting that DDR can have both positive and negative effects on vascular aging. Despite the evidence reviewed in this paper, the role of DDR in vascular aging and potential therapeutic targets remain poorly understood and require further investigation.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

基金：
Senior Research Fellowship by Cancer Research UK [grant number BVR01170] awarded to MG, EPA Trust Fund [BVR01670] awarded to MG, Lee Placito Fund awarded to MG, the Natural Science Foundation of China [grant number 82171303] awarded to LJ, Natural Science Foundation of China [grant number 82301468] awarded to TW and Beijing Hospitals Authority’s Ascent Plan [grant number DFL20220702] awarded to LJ.
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]China International Neuroscience Institute (China-INI), Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]China International Neuroscience Institute (China-INI), Beijing 100053, China [6]Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [*1]No. 45 Changchun Street, Xicheng District, Beijing 100053, China. [*2]Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
推荐引用方式(GB/T 7714)：
Zhang Xiao,Zhao Qing,Wang Tao,et al.DNA damage response, a double-edged sword for vascular aging[J].AGEING RESEARCH REVIEWS.2023,92:doi:10.1016/j.arr.2023.102137.
APA：
Zhang Xiao,Zhao Qing,Wang Tao,Long Qilin,Sun Yixin...&Gullerova Monika.(2023).DNA damage response, a double-edged sword for vascular aging.AGEING RESEARCH REVIEWS,92,
MLA：
Zhang Xiao,et al."DNA damage response, a double-edged sword for vascular aging".AGEING RESEARCH REVIEWS 92.(2023)

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