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Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy

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收录情况： ◇ SCIE

作者：
Liu Feng-Tao[1] * ; Lu Jia-Ying[2] ; Li Xin-Yi[1] ; Ge Jing-Jie[2] ; Sun Yi-Min[1] ; Yen Tzu-Chen[3] ; Jiao Fang-Yang[2] ; Chen Ming-Jia[1] ; Zhao Jun[4] ; Yao Rui-Xin[1] ; Tang Gan[1] ; Xu Hao[5] ; Lan Xiao-Li[6] ; Lu Jie[7] ; Cui Rui-Xue[8] ; Brendel Matthias[9,10,11] ; Shi Kuangyu[12,13] ; Guan Yi-Hui[2] ; Rominger Axel[12] ; Wang Jian[1] ; Zuo Chuan-Tao[2,14,15] ;
机构： [1]Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China [2]Department of Nuclear Medicine & PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China [3]APRINOIA Therapeutics Co Ltd, Suzhou, China [4]Department of Nuclear Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China [5]Department of Nuclear Medicine and PET/CT‑MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, China [6]Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [7]Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China [8]Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China [9]Department of Nuclear Medicine, University Hospital of Munich, LMU, Munich, Germany [10]DZNE – German Center for Neurodegenerative Diseases, Munich, Germany [11]Munich Cluster for Systems Neurology (SyNergy), Munich, Germany [12]Department of Nuclear Medicine, Inselspital, University of Bern, Bern, Switzerland [13]Department of Informatics, Technische Universitat Munchen, Munich, Germany [14]International Human Phenome Institutes (Shanghai), Shanghai, China [15]Human Phenome Institute, Fudan University, Shanghai, China
出处：
DOI： 10.1007/s00259-024-06923-3
ISSN：

关键词： Progressive supranuclear palsy [18F]Florzorotau Positron emission tomography Visual reading algorithm

摘要：
The identification of tau accumulation within living brains holds significant potential in facilitating accurate diagnosis of progressive supranuclear palsy (PSP). While visual assessment is frequently employed, standardized methods for tau positron emission tomography (PET) specifically in PSP are absent. We aimed to develop a visual reading algorithm dedicated to the evaluation of [18F]Florzolotau PET in PSP.148 PSP and 30 healthy volunteers were divided into a development set (for the establishment of the reading rules; n = 89) and a testing set (for the validation of the reading rules; n = 89). For differential diagnosis, 55 α-synucleinopathies were additionally included into the testing set. The visual reading method was established by an experienced assessor (Reader 0) and was then validated by Reader 0 and two additional readers on regional and overall binary manners. A positive binding in both midbrain and globus pallidus/putamen regions was characterized as a PSP-like pattern, whereas any other pattern was classified as non-PSP-like.Reader 1 (94.4%) and Reader 2 (93.8%) showed excellent agreement for the overall binary determination against Reader 0. The regional binary determinations of midbrain and globus pallidus/putamen showed excellent agreement among readers (kappa > 0.80). The overall binary evaluation demonstrated reproducibility of 86.1%, 94.4% and 77.8% for three readers. The visual reading algorithm showed high agreement with regional standardized uptake value ratios and clinical diagnoses.Through the application of the suggested visual reading algorithm, [18F]Florzorotau PET imaging demonstrated a robust performance for the imaging diagnosis of PSP.© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

基金：
This work was funded by research grants from the National Natural Science Foundation of China (82272039, 82021002, 82394430, 81971641, 82371266, 82171252, 82171421, 91949118, 82394434), the Science and Technology Innovation 2030 Major Project (2022ZD0211600), the National Key R&D Program of China (2022YFC2009902, 2022YFC2009900), the Shanghai Municipal Science and Technology Major Project (2018SHZDZX01 and 21S31902200), the ZHANGJIANG LAB, the National Health Commission of PRC (Pro20211231084249000238), the Research Project of the Shanghai Health Commission (2020YJZX0111), the Medical Innovation Research Project of the Shanghai Science and Technology Commission (21Y11903300), the Deutsche Forschungsgemeinschaft (DFG) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198).
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外文
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出版当年[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 核医学
JCR分区：
出版当年[2022]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Neurology, National Research Center for Aging and Medicine, National Center for Neurological Disorders, and State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China
通讯作者：
通讯机构： [2]Department of Nuclear Medicine & PET Center, National Center for Neurological Disorders, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China [14]International Human Phenome Institutes (Shanghai), Shanghai, China [15]Human Phenome Institute, Fudan University, Shanghai, China
推荐引用方式(GB/T 7714)：
Liu Feng-Tao,Lu Jia-Ying,Li Xin-Yi,et al.Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy[J].European Journal Of Nuclear Medicine And Molecular Imaging.2024,doi:10.1007/s00259-024-06923-3.
APA：
Liu Feng-Tao,Lu Jia-Ying,Li Xin-Yi,Ge Jing-Jie,Sun Yi-Min...&Zuo Chuan-Tao.(2024).Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy.European Journal Of Nuclear Medicine And Molecular Imaging,,
MLA：
Liu Feng-Tao,et al."Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy".European Journal Of Nuclear Medicine And Molecular Imaging .(2024)

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