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N-myc downstream-regulated gene 2, co-regulated by transcription factors c-MYC and SP1, reduces cell proliferation by interacting with mTOR in GBM

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China [2]Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China [3]Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China. [4]Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, China. [5]Department of Neurosurgery, Benq Medical Center, Nanjing Medical University, Nanjing, China. [6]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.

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关键词： NDRG2 Glioblastoma mTOR C-MYC SP1

摘要：

NDRG2, a recognized suppressor of tumor cell proliferation, displays downregulation in glioma, yet its specific regulatory mechanisms remain elusive. Our study validated the downregulation of NDRG2 in surgical glioma samples from our center and confirmed its antitumor effects both in vitro and in vivo. Utilizing chromatin immunoprecipitation and dual luciferase reporter assays, we identified MYC and SP1 as negative transcription factors that regulate NDRG2 expression. Furthermore, we identified NDRG2 as a novel binding partner of mTOR, a pivotal regulator of cell growth and proliferation, inhibiting the phosphorylation of mTOR. The downstream signaling pathway of mTOR was then inhibited by overexpression of NDRG2. It suggested a potential mechanism by which NDRG2 exerted its antitumor function. Our findings shed light on the intricate regulatory network involving NDRG2 in glioma development and offer insights into novel therapeutic strategies targeting this pathway.Copyright © 2025. Published by Elsevier B.V.

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出版当年[2025]版：

大类 | 2 区生物学

小类 | 2 区生物物理 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生物物理 3 区生化与分子生物学

JCR分区：

出版当年[2023]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.2 最新[2023版] 5.5 最新五年平均 4.2 出版当年[2023版] 5.5 出版当年五年平均 6.2 出版前一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China [2]Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China [3]Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

通讯作者：

通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China [2]Brain Research Innovation and Transformation Laboratory, Xuanwu Hospital Capital Medical University, Beijing, China [3]Department of Neurosurgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China. [5]Department of Neurosurgery, Benq Medical Center, Nanjing Medical University, Nanjing, China. [6]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China.

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N-myc downstream-regulated gene 2, co-regulated by transcription factors c-MYC and SP1, reduces cell proliferation by interacting with mTOR in GBM

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