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Single-nucleus Transcriptomics Decodes the Link Between Aging and Lumbar Disc Herniation

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Pubmed体系：

收录情况： ◇ 统计源期刊 ◇ 卓越：梯队期刊

作者：
Wang Min[1,2] * ; He Zan[3] * ; Wang Anqi[4,5] * ; Sun Shuhui[1,6,7,8] * ; Li Jiaming[6,9] ; Liu Feifei[8] ; Li Chunde[5] ; Yang Chengxian[5] ; Lei Jinghui[3,10] ; Yu Yan[1,6,7] ; Ma Shuai[1,6,7,11] ; Wang Si[3,10,11] ; Zhang Weiqi[6,9,11] ; Yu Zhengrong[5] ; Liu Guang-Hui[1,3,6,7,10,11] ; Qu Jing[1,6,7,8,11] ;
机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [2]Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China. [3]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [4]Department of Musculoskeletal Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. [5]Department of Orthopaedics, Peking University First Hospital, Beijing 100034, China. [6]University of Chinese Academy of Sciences, Beijing 100049, China. [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China. [8]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. [9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. [10]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [11]Aging Biomarker Consortium, Beijing 100101, China.
出处：
DOI： 10.1093/procel/pwaf025
ISSN：

关键词： aging herniation nucleus pulposus (NP) single-nucleus transcriptomics NFAT1 senescence

摘要：
Lumbar disc (LD) herniation and aging are prevalent conditions that can result in substantial morbidity. This study aimed to clarify the mechanisms connecting the LD aging and herniation, particularly focusing on cellular senescence and molecular alterations in the nucleus pulposus (NP). We performed a detailed analysis of NP samples from a diverse cohort, including individuals of varying ages and those with diagnosed LD herniation. Our methodology combined histological assessments with single-nucleus RNA sequencing to identify phenotypic and molecular changes related to NP aging and herniation. We discovered that cellular senescence and a decrease in nucleus pulposus progenitor cells (NPPCs) are central to both processes. Additionally, we found an age-related increase in NFAT1 expression that promotes NPPC senescence and contributes to both aging and herniation of LD. This research offers fresh insights into LD aging and its associated pathologies, potentially guiding the development of new therapeutic strategies to target the root causes of LD herniation and aging.© The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Press.

基金：
This work was supported by the National Natural Science Foundation of China (82488301, 82125011, 92168201, 82361148131, 82322025), the National Key Research and Development Program of China (2020YFA0804000, 2022YFA1103700, 2022YFA1103800, the STI2030-Major Projects-2021ZD0202400), the National Natural Science Foundation of China (82422031, 82330044, 32341001, 32121001, 82192863, 82361148130, 8231101626, 82271600, 82471586, 92468303), the Program of the Beijing Natural Science Foundation (JQ24044, Z240018, Z230011), Shenzhen Medical Research Fund (C2406001), CAS Project for Young Scientists in Basic Research (YSBR-076, YSBR-012), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA0460403, XDC0200000). the Informatization Plan of Chinese Academy of Sciences (CAS-WX2022SDC-XK14), New Cornerstone Science Foundation through the XPLORER PRIZE (2021-1045), Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (JYY2023-13), CAS Youth Interdisciplinary Team, Space Medical Experiment Project of CMSP (HYZHXMH01012), Key Laboratory of Alzheimer's Disease of Zhejiang Province (ZJAD-2024001), Initiative Scientific Research Program, Institute of Zoology, CAS (2023IOZ0202, 2024IOZ0103, 2023IOZ0102), Excellent Young Talents Program of Capital Medical University (12300927), Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team (BPHR202203105), Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), and Youth Innovation Promotion Association of CAS (2022083).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学
第一作者：
第一作者机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [2]Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. [3]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [6]University of Chinese Academy of Sciences, Beijing 100049, China. [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China. [8]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. [9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China. [10]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China. [11]Aging Biomarker Consortium, Beijing 100101, China.
推荐引用方式(GB/T 7714)：
Wang Min,He Zan,Wang Anqi,et al.Single-nucleus Transcriptomics Decodes the Link Between Aging and Lumbar Disc Herniation[J].Protein & Cell.2025,doi:10.1093/procel/pwaf025.
APA：
Wang Min,He Zan,Wang Anqi,Sun Shuhui,Li Jiaming...&Qu Jing.(2025).Single-nucleus Transcriptomics Decodes the Link Between Aging and Lumbar Disc Herniation.Protein & Cell,,
MLA：
Wang Min,et al."Single-nucleus Transcriptomics Decodes the Link Between Aging and Lumbar Disc Herniation".Protein & Cell .(2025)

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