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Deciphering aging at three-dimensional genomic resolution

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机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China [6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [8]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA [9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China [10]China National Center for Bioinformation, Beijing, 100101, China
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关键词: Aging Senescence Epigenome 3D genome Epigenetic entropy Transcription regulation Biomarker

摘要:
Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases. Epigenetic alteration is a hallmark of aging, senescent cells show epigenomic changes at multiple scales, such as 3D genome reorganization, alterations of histone modifications and chromatin accessibility, and DNA hypomethylation. Chromosome conformation capture (3C)-based technologies have enabled the generation of key information on genomic reorganizations during senescence. A comprehensive understanding of epigenomic alterations during aging will yield important insights into the underlying epigenetic mechanism for aging regulation, the identification of aging-related biomarkers, and the development of potential aging intervention targets.

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第一作者机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China
通讯作者:
通讯机构: [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China [3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China [4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China [5]University of Chinese Academy of Sciences, Beijing, 100049, China [6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China [9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China [10]China National Center for Bioinformation, Beijing, 100101, China
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