机构:[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China[4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China[5]University of Chinese Academy of Sciences, Beijing, 100049, China[6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China首都医科大学宣武医院[7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China首都医科大学宣武医院[8]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA[9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China[10]China National Center for Bioinformation, Beijing, 100101, China
Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases. Epigenetic alteration is a hallmark of aging, senescent cells show epigenomic changes at multiple scales, such as 3D genome reorganization, alterations of histone modifications and chromatin accessibility, and DNA hypomethylation. Chromosome conformation capture (3C)-based technologies have enabled the generation of key information on genomic reorganizations during senescence. A comprehensive understanding of epigenomic alterations during aging will yield important insights into the underlying epigenetic mechanism for aging regulation, the identification of aging-related biomarkers, and the development of potential aging intervention targets.
基金:
National Key Research and Development Program of China [2020YFA0804000]; Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16010000]; National Natural Science Foundation of China [81921006, 82125011, 92149301, 92168201, 91949209, 92049116, 32121001]; Program of the Beijing Natural Science Foundation [Z190019]; National Key Research and Development Program of China [2018YFC2000100]; CAS Project for Young Scientists in Basic Research [YSBR-012]; Tencent Foundation [2021-1045]; Milky Way Research Foundation (MWRF); Moxie Foundation
语种:
外文
被引次数:
WOS:
PubmedID:
第一作者:
第一作者机构:[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China[4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China[5]University of Chinese Academy of Sciences, Beijing, 100049, China
通讯作者:
通讯机构:[1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China[3]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China[4]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China[5]University of Chinese Academy of Sciences, Beijing, 100049, China[6]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China[7]Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China[9]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China[10]China National Center for Bioinformation, Beijing, 100101, China
推荐引用方式(GB/T 7714):
Liu Zunpeng,Belmonte Juan Carlos Izpisua,Zhang Weiqi,et al.Deciphering aging at three-dimensional genomic resolution[J].CELL INSIGHT.2022,1(3):doi:10.1016/j.cellin.2022.100034.
APA:
Liu, Zunpeng,Belmonte, Juan Carlos Izpisua,Zhang, Weiqi,Qu, Jing&Liu, Guang-Hui.(2022).Deciphering aging at three-dimensional genomic resolution.CELL INSIGHT,1,(3)
MLA:
Liu, Zunpeng,et al."Deciphering aging at three-dimensional genomic resolution".CELL INSIGHT 1..3(2022)