Objective The National Institutes of Health Stroke Scale (NIHSS) is a known risk factor for post-stroke depression (PSD). However, more objective indicators are needed. The role of neuron-specific enolase (NSE) in PSD development remains unclear. This study aimed to ascertain the correlation of NIHSS score and NSE with PSD risk, and establish a novel nomogram combining NSE and NIHSS for early PSD prediction. Methods A total of 172 patients with acute ischemic stroke (AIS) were involved. Baseline clinical data including NSE and NIHSS were collected. At 3-month follow-up, patients were categorized into PSD and non-PSD groups. Logistic models and restricted cubic spline curve were used to investigate the correlation between NIHSS, NSE and PSD. A corresponding nomogram was formulated. Results Among 172 patients with AIS, 63 (36.63%) were diagnosed with PSD, while 109 (63.37%) were non-PSD. The baseline NIHSS and NSE were positively correlated with the risk of 3-month PSD (P < 0.05). Multivariate logistic regression revealed that sex (OR= 2.168, 95% CI 1.038 similar to 4.526), age (OR= 1.035, 95% CI 1.002 similar to 1.070), NIHSS (OR= 1.164, 95% CI 1.022 similar to 1.325) and NSE (OR= 1.180, 95% CI 1.037 similar to 1.343) were independently associated with 3-month PSD (all P < 0.05). The nomogram constructed using sex, age, baseline NIHSS score and NSE showed good discrimination, calibration, and clinical utility. Conclusion NSE is a valuable tool for early identification of PSD risk. A combined prediction model incorporating NIHSS and NSE has been established for the personalized prevention and intervention of PSD.
基金：
National Natural Science Foundation of China [81973759, 82274444]; National Key R&D Program of China [2020YFC2003103]
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Neurol Dept, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yan Chuming,Zheng Wancheng,Si Tong,et al.Nomogram combined neuron-specific enolase and NIHSS for prediction of post stroke depression[J].INTERNATIONAL JOURNAL OF NEUROSCIENCE.2025,doi:10.1080/00207454.2025.2488758.
APA：
Yan, Chuming,Zheng, Wancheng,Si, Tong,Huang, Liyuan,Wen, Lulu...&Qu, Miao.(2025).Nomogram combined neuron-specific enolase and NIHSS for prediction of post stroke depression.INTERNATIONAL JOURNAL OF NEUROSCIENCE,,
MLA：
Yan, Chuming,et al."Nomogram combined neuron-specific enolase and NIHSS for prediction of post stroke depression".INTERNATIONAL JOURNAL OF NEUROSCIENCE .(2025)
