机构：[1]Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100071, China.[2]China-America Institute of Neuroscience and Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.内科系统科技平台老年医学科中美神经科学研究所首都医科大学宣武医院[3]Beijing Institute of Brain Disorders, Capital Medical University, Beijing, 100069, China.[4]Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.[5]School of Life Science, Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan, 430056, China.[6]Beijing Laboratory of Oral Health, Capital Medical University, Beijing, 100069, China.[7]Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.首都医科大学附属天坛医院
Enhanced bone healing within 1 week after post-titanium (Ti) dental implant surgery especially contributes to the subsequent long-term osseointegration, and the commonly used drug-loaded TiO2 nanotubes (TNTs) can promote osteogenesis yet still face the challenge of burst drug release that makes it difficult to maintain long-term effective drug concentrations and good osseointegration. Here, we prepared a double drug loading/release system of silk fibroin/mesoporous silica nanoparticles (SF/MSN) nanocomposite coating modified TNTs (TAMA) with AZD2858 (Wnt/β-catenin pathway agonist for promoting osteogenesis) as the therapeutic drug, realizing a long-term stable drug release and better osteogenesis. The increased β-sheet content of SF reduced the degradation rate of the SF/MSN coating, thus avoiding the AZD2858 burst release. The adsorption of MSN maintained the effective drug concentration more than 1 week that was especially critical for early bone healing. Under the protection of SF/MSN coating, the TAMA implant showed a well-organized spatial release of AZD2858, well enabling the osteogenic differentiation and mineralization at cellular level for up to 21 days. Animal experiments further demonstrated that the slow release of AZD2858 in the TAMA implant effectively activated the Wnt/β-catenin pathway, enabling rapid bone healing in the early stage of implantation and finally achieving the best osseointegration efficacy. Thus, this study proposed an efficient strategy for developing high-performance dental implants via the construction of a biodegradable SF/MSN coating.
基金：
This work was supported by Young Scientist Program of
Beijing Stomatological Hospital, Capital Medical University (No. YSP202414); the Beijing Natural Science Foundation
(7252279); the National Natural Science Foundation of China
(82170951, 22204107); the Beijing Hospital Authority
“Dengfeng” Talent Training Plan (DFL 20221301); the
Jianghan University first-class discipline major special grant
program (2023XKZ019); the Beijing Association for Science
and Technology Youth Talent Support Program (BYESS2-
023233).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
最新[2025]版：
大类|2 区材料科学
小类|2 区材料科学：综合2 区纳米科技
第一作者：
第一作者机构：[1]Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100071, China.
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100071, China.[6]Beijing Laboratory of Oral Health, Capital Medical University, Beijing, 100069, China.[7]Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
推荐引用方式(GB/T 7714)：
Mu Yanting,Li Ming,Zhao Xiang,et al.TiO2 Nanotube Implants Modified with Silk Fibroin and Mesoporous Silica Nanocomposite Coatings Enable Efficient Drug Release to Promote Osteogenesis[J].ACS Applied Materials & Interfaces.2025,doi:10.1021/acsami.5c03599.
APA：
Mu Yanting,Li Ming,Zhao Xiang,Gong Chaihong,Luo Zhang...&Zhou Jian.(2025).TiO2 Nanotube Implants Modified with Silk Fibroin and Mesoporous Silica Nanocomposite Coatings Enable Efficient Drug Release to Promote Osteogenesis.ACS Applied Materials & Interfaces,,
MLA：
Mu Yanting,et al."TiO2 Nanotube Implants Modified with Silk Fibroin and Mesoporous Silica Nanocomposite Coatings Enable Efficient Drug Release to Promote Osteogenesis".ACS Applied Materials & Interfaces .(2025)
