机构：[1]Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China[2]Department of Rehabilitation Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China[3]Jiangsu Stroke Research Collaborative Group, Nanjing 210008, China[4]Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing 210008, China[5]Department of Neurology, Northern Jiangsu People’s Hospital, Yangzhou 225001, China[6]Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China[7]Department of Neurology, Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210019, China[8]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[9]Department of Neurology, The Affiliated Huaian First People’s Hospital of Nanjing Medical University, Huaian 223300, China[10]Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China[11]Department of Neurology, Affiliated Xuzhou Central Hospital of Xuzhou Medical College, Xuzhou 221009, China[12]Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang 212002, China[13]Department of Neurology, Jiangyin People’s Hospital, Jiangyin 214400, China[14]Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China[15]Department of Neurology, The First People’s Hospital of Lianyungang, Lianyungang 222002, China[16]Department of Neurology, The First Affiliated Hospital of Xuzhou Medical College, Xuzhou 221000, China[17]Department of Neurology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China[18]Department of Neurology, Gaochun People’s Hospital, Nanjing 211300, China[19]Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing 210008, China[20]Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China
The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation (AF) is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome (P < 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were: heart failure (P = 0.045); high systolic pressure (P = 0.039); high blood glucose (P = 0.030); and a high National Institutes of Health Stroke Scale (NIHSS) score (P < 0.001). Moreover, high systolic pressure at admission (P = 0.007), high blood glucose (P = 0.027), and a high NIHSS score (P < 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score (P = 0.006) and warfarin taken within 48 h before stroke onset (P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke.
基金：
This work was supported by the National Natural
Science Foundation of China (81230026 and 81171085), the
Natural Science Foundation of Jiangsu Province, China (BL2012013),
and the Science Foundation of the Bureau of Health of Jiangsu Province,
China (LJ201101).
第一作者机构：[1]Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China[2]Department of Rehabilitation Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China[3]Jiangsu Stroke Research Collaborative Group, Nanjing 210008, China[4]Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing 210008, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China[3]Jiangsu Stroke Research Collaborative Group, Nanjing 210008, China[4]Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing 210008, China[19]Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing 210008, China[20]Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing 210008, China
推荐引用方式(GB/T 7714)：
Qiuyun Zhao,Xiaobo Li,Wanli Dong,et al.Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation[J].NEUROSCIENCE BULLETIN.2016,32(2):145-52.doi:10.1007/s12264-016-0019-8.
APA：
Qiuyun Zhao,Xiaobo Li,Wanli Dong,Min Ye,Yongjun Cao...&Yun Xu.(2016).Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation.NEUROSCIENCE BULLETIN,32,(2)
MLA：
Qiuyun Zhao,et al."Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation".NEUROSCIENCE BULLETIN 32..2(2016):145-52
