机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, Soochow University, Suzhou City, China[2]The Institute of Neuroscience, Soochow University, Suzhou City, China[3]The Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou City, China[4]The Cecile Cox Quillen Laboratory of Geriatric Research, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA[5]Department of Neurology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA.
Oligodendrocytes are the predominant cell type in white matter and are highly vulnerable to ischemic injury. The role of oligodendrocyte dysfunction in ischemic brain injury is unknown. In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model. Intraperitoneal HNG pre-treatment decreased infarct volume following H/I injury. Delayed HNG treatment 24 h after H/I injury did not reduce infarct volume but did decrease neurological deficits and brain atrophy. Delayed HNG treatment did not attenuate axonal demyelination at 48 h after H/I injury. However, at 14 d after H/I injury, delayed HNG treatment increased axonal remyelination, the thickness of corpus callosum at the midline, the number of Olig2(+)/BrdU(+) cells, and levels of brain-derived neurotrophic factor (BDNF). Our results suggest that targeting oligodendrogenesis via delayed HNG treatment may represent a promising approach for the treatment of stroke. (c) 2014 Wiley Periodicals, Inc.
基金：
Grant sponsor: National Natural Science Foundation of China; Grant
number: 81071095, 81120108011, 81361128010 (to X.X.), and
81301011 (to C.J.); Grant sponsor: National Basic Research Program of
China; Grant number: 2013CB945400 (to S.M.); Grant sponsors: Priority
Academic Program Development of Jiangsu Higher Education Institutions
of China (to X.X.), Jiangsu Province’s Key Provincial Talents Program;
Grant sponsor: Suzhou science and technology development program;
Grant number: SYSD2011087 (to Z.X.).
第一作者机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, Soochow University, Suzhou City, China[2]The Institute of Neuroscience, Soochow University, Suzhou City, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu 215004,China.
推荐引用方式(GB/T 7714)：
Jing Chen,Miao Sun,Xia Zhang,et al.Increased Oligodendrogenesis by Humanin Promotes Axonal Remyelination and Neurological Recovery in Hypoxic/Ischemic Brains[J].HIPPOCAMPUS.2015,25(1):62-71.doi:10.1002/hipo.22350.
APA：
Jing Chen,Miao Sun,Xia Zhang,Zhigang Miao,Balvin H. L. Chua...&Xingshun Xu.(2015).Increased Oligodendrogenesis by Humanin Promotes Axonal Remyelination and Neurological Recovery in Hypoxic/Ischemic Brains.HIPPOCAMPUS,25,(1)
MLA：
Jing Chen,et al."Increased Oligodendrogenesis by Humanin Promotes Axonal Remyelination and Neurological Recovery in Hypoxic/Ischemic Brains".HIPPOCAMPUS 25..1(2015):62-71
