机构：[1]Department of Neurology, Xuan Wu Hospital Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[2]Department of Neurology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China,[3]Department of Clinical Psychology, Beijing Anding Hospital, Beijing, China,[4]Nanjing Municipal Hospital of Traditional Chinese Medicine, Nanjing, China,[5]Department of Neurology, Fengtai Integrated Chinese and Western Medicine Hospital of Beijing, Beijing, China,[6]Department of Radiology, Guang’ anmen Hospital China Academy of Chinese Medical Sciences, Beijing, China,[7]Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Childhood Maltreatment (CM) is an important risk factor for major depressive disorder (MDD). Previous studies using emotional task-state functional magnetic resonance (task-state fMRI) found that altered brain function in prefrontal-limbic regions was the key neuropathological mechanism in adult MDD patients with experience of early-life maltreatment. However, to the best of our knowledge, there is no published study investigating brain function in MDD patients with CM experience using resting-state fMRI (rs-fMRI). In present study, we aimed to detect altered resting-state brain activity in MDD patients with CM experience, and identify significantly activated brain regions, which may provide new insights into the neural mechanism underlying the relationship between MDD and CM experience. The results showed MDD patients with CM experience were associated with increased amplitude of low-frequency fluctuation (ALFF) and altered function connection (FC) in the prefrontal cortex, when compared to MDD patients without CM. Of note, left frontal middle gyrus (LFEG) was found as a specific brain region which differentiates MDD patients with CM from patients without CM. These results suggest that rs-fMRI is a useful method in studying the correlation between MDD and CM experience and altered function of LFEG in resting-state may explain the correlation between MDD and CM experience.
基金：
National Natural Science Foundation of China [81573905]; Excellent Project of Beijing Municipal Science and Technology Commission [Z141107002514080]
第一作者机构：[1]Department of Neurology, Xuan Wu Hospital Capital Medical University, Beijing, China,[2]Department of Neurology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuan Wu Hospital Capital Medical University, Beijing, China,[2]Department of Neurology, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China,[6]Department of Radiology, Guang’ anmen Hospital China Academy of Chinese Medical Sciences, Beijing, China,
推荐引用方式(GB/T 7714)：
Xu Zhexue,Zhang Jing,Wang Di,et al.Altered Brain Function in Drug-Naive Major Depressive Disorder Patients With Early-Life Maltreatment: A Resting-State fMRI Study[J].FRONTIERS IN PSYCHIATRY.2019,10:doi:10.3389/fpsyt.2019.00255.
APA：
Xu, Zhexue,Zhang, Jing,Wang, Di,Wang, Ting,Zhang, Shu...&Qu, Miao.(2019).Altered Brain Function in Drug-Naive Major Depressive Disorder Patients With Early-Life Maltreatment: A Resting-State fMRI Study.FRONTIERS IN PSYCHIATRY,10,
MLA：
Xu, Zhexue,et al."Altered Brain Function in Drug-Naive Major Depressive Disorder Patients With Early-Life Maltreatment: A Resting-State fMRI Study".FRONTIERS IN PSYCHIATRY 10.(2019)
