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Altered Resting-State Brain Activities in Drug-NaTve Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by Yin-Yang Theory of the Traditional Chinese Medicine

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, [2]Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China, [3]Department of Neurology, Fengtai Integrated Chinese and Western Medicine Hospital of Beijing, Beijing, China, [4]Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, [5]School of Applied Psychology and Menzies Health Institute Queensland, Griffith University, Brisbane, QLD, Australia, [6]Department of Radiology, People’s Liberation Army No.306 Hospital, Beijing, China, [7]Department of Clinical Psychology, Peking University Sixth Hospital, Beijing, China, [8]Department of Clinical Psychology, Beijing Anding Hospital, Beijing, China, [9]Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States

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关键词： major depressive disorder somatic symptoms resting-state fMRI Yin-Yang theory traditional Chinese medicine

摘要：

Identification of biological markers for defining subtypes of major depressive disorder (MDD) is critical for better understanding MDD pathophysiology and finding effective treatment intervention The "Yin and Yang" theory is a fundamental concept of traditional Chinese Medicine (TCM). The theory differentiates MDD patients into two subtypes, Yin and Yang, based on their somatic symptoms, which had empirically been used for the delivery of effective treatment in East Asia Nonetheless, neural processes underlying Yin and Yang types in MDD are poorly understood In this study, we aim to provide physiological evidence using functional magnetic resonance imaging (fMRI) to identify altered resting-state brain activity associated with Yin and Yang types in drug-naive MDD patients The Yin type and Yang type MDD patients showed increased amplitude of low-frequency fluctuation (ALFF) in different cortical brain areas in the parietal, temporal, and frontal lobe, compared to matched healthy controls Differential ALFF is also observed in several cortical areas in frontal lobe and insula between Yin and Yang type group Of note, although ALFF is increased in the inferior parietal lobe in both Yin and Yang type group, inferior parietal lobe-centered functional connectivity (FC) is increased in Yang type, but is decreased in Ying type, compared with matched healthy controls These results suggest that differential resting-state brain activity and functional connectivity in Yin and Yang types may contribute to biological measures for better stratification of heterogeneous MDD patients.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 3 区精神病学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区精神病学

JCR分区：

出版当年[2016]版：

Q1 PSYCHIATRY Q2 PSYCHIATRY

最新[2023]版：

Q2 PSYCHIATRY

影响因子： 3.2 最新[2023版] 3.9 最新五年平均 3.532 出版当年[2016版] 0 出版当年五年平均 0 出版前一年[2015版] 2.857 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, [2]Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China,

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通讯作者：

通讯机构： [1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China, [2]Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China, [4]Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States,

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Altered Resting-State Brain Activities in Drug-NaTve Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by Yin-Yang Theory of the Traditional Chinese Medicine

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