机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China老年医学科[2]Department of Geriatrics, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang, 110004, China
BackgroundBecause frailty is a major health concern among older patients, identifying frailty-related biomarkers will help in the early detection and prevention of frailty. Thus, we aimed to determine the association between circulating levels of silent mating-type information regulation 2 homolog 1 (SIRT1) and frailty.MethodsWe assessed circulating SIRT1 levels in 16 robust, 74 prefrail, and 40 frail older adults. Frailty was diagnosed based on the Fried phenotype. Circulating cytokine and adipokine (e.g., vaspin, adiponectin, and leptin) levels were assessed. Differences in SIRT1 levels among the three subject groups were compared; correlations of SIRT1 levels with physical function and adipokine and cytokine levels were analyzed.ResultsSerum SIRT1 levels were significantly higher among frail older adults than among robust ones. Older adults with slowness or weight loss had high SIRT1 levels. Serum SIRT1 levels negatively correlated with gait speed, even after adjustment for age and sex; age; and insulin, vaspin, and leptin levels; they correlated negatively with phospholipase A2 levels.ConclusionsHigh SIRT1 levels were observed in frail elderly patients and were correlated with decreased physical function. Insulin and adipokine levels might be the link between SIRT1 and frailty, whereas inflammation may not be involved in this process.
第一作者机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China[*1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing 100053, China[*1]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
L. MA,H. NIU,G. SHA,et al.Serum SIRT1 is Associated with Frailty and Adipokines in Older Adults[J].JOURNAL OF NUTRITION HEALTH & AGING.2019,23(3):246-250.doi:10.1007/s12603-018-1149-7.
APA：
L. MA,H. NIU,G. SHA,Y. ZHANG,P. LIU&Y. LI.(2019).Serum SIRT1 is Associated with Frailty and Adipokines in Older Adults.JOURNAL OF NUTRITION HEALTH & AGING,23,(3)
MLA：
L. MA,et al."Serum SIRT1 is Associated with Frailty and Adipokines in Older Adults".JOURNAL OF NUTRITION HEALTH & AGING 23..3(2019):246-250
