机构：[a]Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China首都医科大学宣武医院[b]Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China,[c]HuangHuai University, Zhumadian 463000, P. R. China[d]Pony Testing International Group Co. Ltd. (Wuhan), Wuhan 430034, P. R. China,
A new class of 1-[(1R,2S)-2-fluorocyclopropyl]ciprofloxacin (CPFX)-1,2,4-triazole-5(4H)-thione hybrids 6a-6o was designed, synthesized and evaluated for their invitro antibacterial activities against a panel of clinically important drug-sensitive and drug-resistant Gram-positive and Gram-negative pathogens. Our results revealed that all hybrids 6a-6o had great potency against the tested strains, especially Gram-negative pathogens. The synthesized hybrids were more potent than the parent 1-[(1R,2S)-2-fluorocyclopropyl]CPFX (1) and comparable to CPFX and levofloxacin against the majority of the tested pathogens, worth to be further investigated.
第一作者机构：[a]Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China
共同第一作者：
推荐引用方式(GB/T 7714)：
Yang Gao ,Lu-Xin Na ,Zhi Xu ,et al.Design, Synthesis and Antibacterial Evaluation of 1-[(1R,2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids[J].CHEMISTRY & BIODIVERSITY.2018,15(10):e1800261.doi:10.1002/cbdv.201800261.
APA：
Yang Gao,,Lu-Xin Na,,Zhi Xu,,Shu Zhang,A-Peng Wang,...&Ming-Liang Liu.(2018).Design, Synthesis and Antibacterial Evaluation of 1-[(1R,2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids.CHEMISTRY & BIODIVERSITY,15,(10)
MLA：
Yang Gao,,et al."Design, Synthesis and Antibacterial Evaluation of 1-[(1R,2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids".CHEMISTRY & BIODIVERSITY 15..10(2018):e1800261
