机构：[a]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China中美神经科学研究所首都医科大学宣武医院[b]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China[c]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital of Capital Medical University, Beijing 100053, China首都医科大学宣武医院[d]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经外科首都医科大学宣武医院[e]Department of Biomedical Engineering, Columbia University, New York, NY 10032, USA[f]Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds. The last few years witnessed increasing numbers of studies on the preparation, mechanical and biological evaluations of these novel materials. Herein, various preparation techniques, mechanical behaviors and toughen mechanism, the in vitro/in vivo biocompatible analysis, antibacterial properties of the graphene-based HA composites are presented in this review. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
基金：
National Natural Science Foundation of China (No. 31370954, 31670974)
Beijing Natural Science Foundation (2164073).
第一作者机构：[a]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[b]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China[c]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[b]Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
推荐引用方式(GB/T 7714)：
Ming Li,Pan Xiong,Feng Yan,et al.An overview of graphene-based hydroxyapatite composites for orthopedic applications[J].BIOACTIVE MATERIALS.2018,3(1):1-18.doi:10.1016/j.bioactmat.2018.01.001.
APA：
Ming Li,Pan Xiong,Feng Yan,Sijie Li,Changhong Ren...&Yan Cheng.(2018).An overview of graphene-based hydroxyapatite composites for orthopedic applications.BIOACTIVE MATERIALS,3,(1)
MLA：
Ming Li,et al."An overview of graphene-based hydroxyapatite composites for orthopedic applications".BIOACTIVE MATERIALS 3..1(2018):1-18
医学