机构：[a]Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, PR China血管外科首都医科大学宣武医院[b]School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, PR China[c]Department of Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing, PR China首都医科大学宣武医院[d]Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery Capital Medical University, No. 45, Changchun Street, Xicheng District Beijing 100053 (PR China)血管外科首都医科大学宣武医院
In the field of vascular graft research, poly-epsilon-caprolactone ( PCL) is used owing to its good mechanical strength and bio-compatibility. In this study, PCL scaffold was prepared by electrospinning and surface modification with heparin via hexamethylenediamine. Then the scaffolds were implanted into the infrarenal abdominal aorta of Wistar rats and contrast-enhanced micro-ultrasound was used to monitor the patency of grafts after implantation. These grafts were extracted from the rats at 1, 3, and 6 months for histological analysis, immunofluorescence staining, and scanning electron microscopy observation. Although some grafts experienced aneurysmal change, results showed that all implanted grafts were patent during the course of 6 months and these grafts demonstrated well-organized neotissue with endothelium formation, smooth muscle regeneration, and extracellular matrix formation. Such findings confirm feasibility to create heparin-conjugated scaffolds of next-generation vascular grafts. (C) 2018 S. Karger AG, Basel.
基金：
National Key R&D Program of China [2017YFC1104100]; Beijing Chinese Medical Science and Technique Development Foundation Project [JJ2015-09]; Beijing Clinical Translational Research of Decellularized Artificial Blood Vessels from the Capital Health Research and Development of Special [2016-1-2012]
第一作者机构：[a]Department of Vascular Surgery, Xuan Wu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing, PR China
推荐引用方式(GB/T 7714)：
Zeqin Xu,Yongquan Gu,Jianxin Li,et al.Vascular Remodeling Process of Heparin-Conjugated Poly(epsilon-Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement Model[J].JOURNAL OF VASCULAR RESEARCH.2018,55(6):338-349.doi:10.1159/000494509.
APA：
Zeqin Xu,Yongquan Gu,Jianxin Li,Zengguo Feng,Lianrui Guo...&Jian Zhang.(2018).Vascular Remodeling Process of Heparin-Conjugated Poly(epsilon-Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement Model.JOURNAL OF VASCULAR RESEARCH,55,(6)
MLA：
Zeqin Xu,et al."Vascular Remodeling Process of Heparin-Conjugated Poly(epsilon-Caprolactone) Scaffold in a Rat Abdominal Aorta Replacement Model".JOURNAL OF VASCULAR RESEARCH 55..6(2018):338-349
