机构：[a]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing, China首都医科大学宣武医院[b]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[c]Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China[d]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China[e]Beijing Geriatric Medical Research Center, Beijing, China
Objective: Because resveratrol (RSV) has been shown to improve learning and memory, so we investigated the potential benefit of RSV on learning and memory deficits in juvenile mice fed with a HC diet and explored the molecular mechanisms underlying this process. Methods: Six-week-old C57BL/6J mice were divided into three different diet groups: control, HC diet, and HC + RSV diet. Serum insulin and insulin-like growth factor 1 (IGF-1) levels were measured using enzyme-linked immunosorbent assays. Protein expression was examined by immunohistochemistry and western blotting. Results: Administration of RSV daily (30 mg/kg) prevented the HC diet-induced increase in juvenile animal body weight but did not improve any other physiological conditions, including fasting blood glucose and serum cholesterol, triglyceride, insulin, and IGF-1 levels. However, RSV did prevent learning and memory deficits in the HC group. Peroxisome proliferator-activated receptor gamma (PPAR gamma) was downregulated in the CA1 region of the hippocampus in both the HC and HC + RSV groups, but the reduction was significantly greater in the HC + RSV group (P < .01 compared with the HC group). Moreover, although the HC diet reduced the number of p16-positive neurons, the HC + RSV diet significantly upregulated p16 expression in the CA1 region of the hippocampus (P < .01 compared with the HC group). Conclusions: RSV protected against learning and memory impairments in juvenile animals fed with a HC diet, possibly via upregulation of p16 or downregulation of PPAR in the hippocampal CA1 region.
基金：
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201706]; National Key Research and Development Program of China [2016YFC1306300]
第一作者机构：[a]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing, China[b]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Medical Research Center[*2]No. 45 Changchun Street, Xicheng District, Beijing 100053, China, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Bao-Lei Xu,Hui Zhang,Li-Na Ma,et al.Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL/6J mice[J].NEUROLOGICAL RESEARCH.2018,40(8):709-715.doi:10.1080/01616412.2018.1471118.
APA：
Bao-Lei Xu,Hui Zhang,Li-Na Ma,Wen Dong,Zhi-Wei Zhao...&Rong Wang.(2018).Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL/6J mice.NEUROLOGICAL RESEARCH,40,(8)
MLA：
Bao-Lei Xu,et al."Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL/6J mice".NEUROLOGICAL RESEARCH 40..8(2018):709-715
