机构：[a]Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China心脏科（内科专业）首都医科大学宣武医院[b]Department of Cardiology, Beijing Tsinghua Changgung Hospital, Beijing, China[c]Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA
A 26-year-old woman, 12 days in postpartum, developed recurrent syncope and cardiac arrest. Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). She also had intermittent LBBB (80 bpm) on alternate beats and RBBB at sinus tachycardia (113 bpm). Family genotyping revealed a novel de novo missense mutation G604C of KCNH2. Propranolol slowed heart rate and further prolonged QT interval (610 ms) that caused TdP recurrence. Mexiletine combined with magnesium and potassium supplements prevented TdP/VF recurrence. This patient has remained event-free after 9-month follow-up. (C) 2017 Elsevier Inc. All rights reserved.
第一作者机构：[a]Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China[*1]Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China
通讯作者：
通讯机构：[*1]Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Chunlin Yin ,Ping Zhang ,Jing Yang ,et al.Unique ECG presentations and clinical management of a symptomatic LQT2 female carrying a novel de novo KCNH2 mutation[J].JOURNAL OF ELECTROCARDIOLOGY.2018,51(1):111-116.doi:10.1016/j.jelectrocard.2017.08.022.
APA：
Chunlin Yin,,Ping Zhang,,Jing Yang,&Li Zhang,.(2018).Unique ECG presentations and clinical management of a symptomatic LQT2 female carrying a novel de novo KCNH2 mutation.JOURNAL OF ELECTROCARDIOLOGY,51,(1)
MLA：
Chunlin Yin,,et al."Unique ECG presentations and clinical management of a symptomatic LQT2 female carrying a novel de novo KCNH2 mutation".JOURNAL OF ELECTROCARDIOLOGY 51..1(2018):111-116
