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Anticancer drugs-related QTc prolongation, torsade de pointes and sudden death: Current evidence and future research perspectives

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机构： [1]Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China [2]Department of Cardiology, Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, P.R. China [3]Department of Cardiology, An Zhen Hospital, Capital Medical University, Beijing, P.R. China [4]Texas Cardiac Arrhythmia Institute at St. David’s Medical Center, Austin, TX, USA

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关键词： Anticancer therapy Molecularly targeted drugs QT interval prolongation Torsade de pointes

摘要：

Anticancer drugs may have proarrhythmic effects including drug-induced QT interval prolongation, which is of particular importance because it can lead to a fatal polymorphic ventricular tachycardia termed torsade de pointes (TdP). QT interval prolongation and TdP are rare life-threatening untoward effects of anticancer therapy, particularly with arsenic trioxides and anthracyclines, and even some novel molecular targeted drugs touted as 'tumor specific'. Several factors that affect myocardial repolarization can further increase the risk of TdP. This article reviews the mechanism of QT interval prolongation, risk factors for TdP and the QT toxicity of anticancer drugs as well as its management. Specific attention should be paid to high-risk populations such as patients with underlying heart diseases, electrolyte imbalance and bradycardia. To minimize the occurrence of QT interval prolongation and TdP, it is advisable to conduct a careful risk factor assessment before antitumor therapy. To this end, several new biomarkers have been introduced to predict TdP triggering and recent studies have pointed out the potential clinical relevance of genetic testing. © Duan et al.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区肿瘤学 3 区细胞生物学

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第一作者：

第一作者机构： [1]Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China

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通讯机构： [1]Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China [3]Department of Cardiology, An Zhen Hospital, Capital Medical University, Beijing, P.R. China [4]Texas Cardiac Arrhythmia Institute at St. David’s Medical Center, Austin, TX, USA

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