机构：[1]Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, The Ninth Academic Hospital of Peking University, Beijing, China[2]Department of Medical Records and Statistics, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[3]Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing, China[4]Department of Cancer Early Detection and Treatment, Yanting Cancer Hospital, Mianyang, China[5]USC Norris Comprehensive Cancer Center, Los Angeles, California, USA[6]Department of Science of Technology, Beijing Shijitan Hospital, Capital Medical University, The Ninth Academic Hospital of Peking University, Beijing, China
Background: Esophageal cancer (EC) is ranked as the top 10th malignancy in China; however, an association between peanut consumption and EC risk has not yet been identified. This study explored the protective effects of peanut consumption against the risk of developing esophageal squamous cell carcinoma (ESCC) in a high-risk area. Methods: A case-control design was applied, with frequency matching by age and gender. A logistic regression model was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Two hundred and twenty-two cases and 222 controls were recruited from Yanting County from 2011 to 2012. Results: Peanut consumption 1-3 times per week reduced cancer risk by 38% (OR 0.62, 95% CI 0.34-1.13), while consumption >= 4 times per week reduced the risk by 70% (OR 0.31, 95% CI 0.16-0.59). A significant association was observed among individuals with negative family EC history (OR 0.25, 95% CI 0.12-0.49). Conclusion: Peanut consumption may act as a protector against the occurrence of ESCC in high-risk areas, thus production and consumption should be promoted in high-risk areas in order to reduce the ESCC burden.
基金：
The Beijing Shijitan Hospital, Capital Medical University (QKS 2014-C01);
the Beijing Municipal Bureau of Health (QKS 2015-3-057);
the Organization Committee of Beijing Municipal (QKS 2014000021469G252)
第一作者机构：[1]Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, The Ninth Academic Hospital of Peking University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Science of Technology, Beijing Shijitan Hospital, Capital Medical University, The Ninth Academic Hospital of Peking University, Tieyi Road 10, Haidian District, 100038 Beijing, China
推荐引用方式(GB/T 7714)：
Yanjie Zhao,Lin Zhao,Zhiping Hu,et al.Peanut consumption associated with a reduced risk of esophageal squamous cell carcinoma: A case-control study in a high-risk area in China[J].THORACIC CANCER.2018,9(1):30-36.doi:10.1111/1759-7714.12520.
APA：
Yanjie Zhao,Lin Zhao,Zhiping Hu,Jiangping Wu,Jun Li...&Qingkun Song.(2018).Peanut consumption associated with a reduced risk of esophageal squamous cell carcinoma: A case-control study in a high-risk area in China.THORACIC CANCER,9,(1)
MLA：
Yanjie Zhao,et al."Peanut consumption associated with a reduced risk of esophageal squamous cell carcinoma: A case-control study in a high-risk area in China".THORACIC CANCER 9..1(2018):30-36
