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Expression of LOX-1 in human mesangial cells is increased by Ox-LDL and IL-1 beta treatment

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收录情况： ◇ SCIE

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机构： [1]Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China

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关键词： oxidized low-density lipoprotein human mesangial cell lectin-like oxidized LDL receptor 1 interleukin 1 beta

摘要：

The present study aimed to determine whether the expression of lectin-like oxidized LDL receptor 1 (LOX-1) could be induced by oxidized low-density lipoprotein (Ox-LDL) and interleukin 1 beta (IL-1 beta) in human mesangial cells (HMCs). Oil Red O staining was used to observe the uptake of Ox-LDL by HMCs stimulated with IL-1 beta, and reverse transcription-quantitative polymerase chain reaction analysis and western blotting were used to examine the expression of LOX-1 in HMC following Ox-LDL and IL-1 beta treatment. Uptake of Ox-LDL by HMCs was upregulated upon stimulation with IL-1 beta. Furthermore, Ox-LDL (10-40 mu g/ml) treatment induced LOX-1 mRNA and protein expression in a dose-dependent manner. In addition, when HMCs were treated with IL-1 beta and Ox-LDL, the expression of LOX-1 was enhanced further. These results indicated that inhibiting LOX-1 expression or inhibiting the Ox-LDL/LOX-1 signaling axis may be a potential novel method for treating renal disease.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2023]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2015]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 2.4 最新[2023版] 2.3 最新五年平均 1.28 出版当年[2015版] 1.326 出版当年五年平均 1.269 出版前一年[2014版] 1.261 出版后一年[2016版]

第一作者：

第一作者机构： [1]Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China

通讯作者：

通讯机构： [*1]Department of Nephrology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, P.R. China

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