机构：[1]Department of Neurology ,Beijing Tiantan Hospital, Capital Medical University, China.重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University, China.重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院
Background and Purpose Oxidized low-density lipoprotein (oxLDL) level is thought to be associated with recurrent stroke. We aimed to investigate the association between oxLDL to high-density lipoprotein (HDL) ratio and recurrent stroke in patients with minor stroke or transient ischemic attack. Methods The study included 3019 patients with minor ischemic stroke or high-risk transient ischemic attack from the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events). Baseline oxLDL and HDL levels were measured. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year and ischemic stroke and combined vascular events within 90 days and 1 year. The association between oxLDL/HDL and recurrent stroke was analyzed by using Cox proportional hazards. Results Patients in the highest oxLDL/HDL quartile had a higher risk of recurrent stroke within 90 days (hazards ratio, 1.50; 95% CI, 1.08-2.08) compared with the lowest quartile after adjusting relevant confounding factors (P=0.02). Similar results were found for secondary outcomes (P<0.05 for all). There were no significant interaction between oxLDL/HDL and use of statins agents. Conclusions Higher serum oxLDL/HDL level in minor stroke or transient ischemic attack was associated with increased risk of recurrent stroke in 90 days and 1 year. OxLDL/HDL may act as a powerful indicator of recurrent stroke in patients with minor stroke or transient ischemic attack. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2013BAI09B03, 2013BAI09B14, 2015BAI12B04, 2015BAI12B02, 2016YFC0901000, 2016YFC0901001, 2016YFC0901002, 2017YFC1310902]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673247, 816005098]; Beijing Biobank of Cerebral Vascular Disease [D131100005313003]; Beijing Institute for Brain Disorders [1152130306]
第一作者机构：[1]Department of Neurology ,Beijing Tiantan Hospital, Capital Medical University, China.[2]China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology ,Beijing Tiantan Hospital, Capital Medical University, China.[2]China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University, China.[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng Dist, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Wang Anxin,Li Shiyu,Zhang Nan,et al.Oxidized Low-Density Lipoprotein to High-Density Lipoprotein Ratio Predicts Recurrent Stroke in Minor Stroke or Transient Ischemic Attack[J].STROKE.2018,49(11):2637-2642.doi:10.1161/STROKEAHA.118.022077.
APA：
Wang, Anxin,Li, Shiyu,Zhang, Nan,Dai, Liye,Zuo, Yingting...&Wang, Yongjun.(2018).Oxidized Low-Density Lipoprotein to High-Density Lipoprotein Ratio Predicts Recurrent Stroke in Minor Stroke or Transient Ischemic Attack.STROKE,49,(11)
MLA：
Wang, Anxin,et al."Oxidized Low-Density Lipoprotein to High-Density Lipoprotein Ratio Predicts Recurrent Stroke in Minor Stroke or Transient Ischemic Attack".STROKE 49..11(2018):2637-2642
医学