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Recent Progress in Vascular Aging: Mechanisms and Its Role in Age-related Diseases

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收录情况： ◇ SCIE

作者：

机构： [1]Zhongshan Hospital, Fudan University, Shanghai 200032, China. [2]Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX 76107, USA. [3]Department of Urology, the First Affiliated Hospital, Zhejiang University, Zhejiang Province, China. [4]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University. Beijing, China. [5]Buck Institute for Research on Aging, Novato, CA 94945, USA. [6]Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.

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关键词： vascular aging stroke dementia arterial stiffness endothelial dysfunction

摘要：

As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGF beta-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.

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中科院(CAS)分区：

出版当年[2016]版中科院分区表Review为是的期刊

：

大类 | 3 区医学

小类 | 3 区老年医学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区老年医学

JCR分区：

出版当年[2015]版：

Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY

影响因子： 7 最新[2023版] 7.1 最新五年平均 3.697 出版当年[2015版] 3.602 出版当年五年平均 3.07 出版前一年[2014版] 4.648 出版后一年[2016版]

第一作者：

第一作者机构： [1]Zhongshan Hospital, Fudan University, Shanghai 200032, China. [2]Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX 76107, USA. [*1]Zhongshan Hospital, Fudan University, Shanghai, China.

通讯作者：

通讯机构： [*1]Zhongshan Hospital, Fudan University, Shanghai, China. [*2]the First Affiliated Hospital, Zhejiang University, China. [*3]University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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