Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis
机构:[1]Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China[2]College of Civil Aviation, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, 210016, China[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China[4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China神经内科首都医科大学宣武医院
Neuroimaging studies have demonstrated that the major depression disorder would increase the risk of dementia in the older with amnestic cognitive impairment. We used granger causality analysis algorithm to explore the amygdala-and hippocampus-based directional connectivity patterns in 12 patients with major depression disorder and amnestic cognitive impairment (mean age: 69.5 +/- 10.3 years), 13 amnestic cognitive impairment patients (mean age: 72.7 +/- 8.5 years) and 14 healthy controls (mean age: 64.7 +/- 7.0 years). Compared with amnestic cognitive impairment patients and control groups respectively, the patients with both major depression disorder and amnestic cognitive impairment displayed increased effective connectivity from the right amygdala to the right lingual and calcarine gyrus, as well as to the bilateral supplementary motor areas. Meanwhile, the patients with both major depression disorder and amnestic cognitive impairment had enhanced effective connectivity from the left superior parietal gyrus, superior and middle occipital gyrus to the left hippocampus, the z values of which was also correlated with the scores of mini-mental state examination and auditory verbal learning test-immediate recall. Our findings indicated that the directional effective connectivity of right amygdala - occipital-parietal lobe - left hippocampus might be the pathway by which major depression disorder inhibited the brain activity in patients with amnestic cognitive impairment.
基金:
The National Key Research and Development Program of China (2016YFC1306300),
Natural Scientific Foundation of China (No. 81322020 and 81230032 and No. 31371007, 81430037, 61633018),
Beijing Nature Science Foundation (7161009),
Beijing Municipal Science & Technology Commission (Z161100002616020),
Fundamental and Clinical Cooperative Research Program of Capital Medical University (16JL-L08),
Health and Family Planning Commission of Shunyi District Beijing,
Opening Foundation of Key Laboratory of Behavioral Science, Chinese Academy of Sciences
第一作者机构:[1]Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Medical Imaging, Medical Imaging Center, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China[4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China
推荐引用方式(GB/T 7714):
Li Juan Zheng,Gui Fen Yang,Xin Yuan Zhang,et al.Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis[J].ONCOTARGET.2017,8(15):25021-25031.doi:10.18632/oncotarget.15335.
APA:
Li Juan Zheng,Gui Fen Yang,Xin Yuan Zhang,Yun Fei Wang,Ya Liu...&Ying Han.(2017).Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis.ONCOTARGET,8,(15)
MLA:
Li Juan Zheng,et al."Altered amygdala and hippocampus effective connectivity in mild cognitive impairment patients with depression: a resting-state functional MR imaging study with granger causality analysis".ONCOTARGET 8..15(2017):25021-25031