机构：[a]Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China内分泌科老年医学科首都医科大学宣武医院[b]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China老年医学科首都医科大学宣武医院[c]Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China老年医学科首都医科大学宣武医院[d]Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China神经内科老年医学科首都医科大学宣武医院[e]Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Beijing 100053, China[f]Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing 100053, China[g]Beijing Key Laboratory for Parkinson’s Disease, Beijing 100053, China[h]Evidence-Based Medicine Center, Xuanwu Hospital of Capital Medical University, Beijing 100053, China首都医科大学宣武医院
The relationship between serum uric acid (sUA) and cognitive function is contradictory. This study assessed the association between sUA and cognitive impairment in 10,039 community-dwelling subjects aged >= 55 years living in Beijing, China. Participants underwent determination of sUA and an evaluation of cognitive function using the scholarship-adjusted Mini-Mental State Examination (MMSE): MMSE <= 17 for illiterates; MMSE <= 20 for primary school graduates (>= 6 years of education); and MMSE <= 24 for junior school graduates or above (>= 9 years of education). Among the 10016 persons with valid MMSE scores, the prevalence of cognitive impairment was 9.14%. A multivariate logistic regression model including demographic, clinical and genetic parameters was performed to assess the relationship between sUA and cognitive impairment. Persons with cognitive impairment had lower sUA levels than those with normal cognitive function: (302.30 +/- 82.80 vs. 312.20 +/- 84.01,mu mol/L, p =0.001). After adjusting for age, sex, lifestyle, relevant diseases and the apolipoprotein E (APOE) epsilon 4 allele, stepwise logistic regression showed that participants with higher levels of sUA had a lower risk of cognitive impairment (hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.62-0.96; p = 0.022). In this baseline cross-sectional population-based sample, high levels of sUA were associated with a decreased risk of cognitive impairment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
基金：
theBeijing Municipal Commission on Science and Technology(D07050701130000 and D07050701130701),
Ministry ofHealth of China (201002011),
Ministry of Science and Technol-ogy of China (2012AA02A514, 0S2012GR0150, 2012ZX09303-005),
Beijing Municipal Administration of Hospitals (ZYLX201301).
第一作者机构：[a]Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China[c]Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China
通讯作者：
通讯机构：[*1]Department of Neurobiology, Geriatrics, and Neurology, Xuanwu Hospital, No. 45 Changchun St., Xicheng District, Beijing, China.
推荐引用方式(GB/T 7714)：
Shuangling Xiu,Zheng Zheng,Shaochen Guan,et al.Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing[J].NEUROSCIENCE LETTERS.2017,637:182-187.doi:10.1016/j.neulet.2016.11.013.
APA：
Shuangling Xiu,Zheng Zheng,Shaochen Guan,Jin Zhang,Jinghong Ma&Piu Chan.(2017).Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing.NEUROSCIENCE LETTERS,637,
MLA：
Shuangling Xiu,et al."Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing".NEUROSCIENCE LETTERS 637.(2017):182-187
