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Long-term caloric restriction in mice may prevent age-related learning impairment via suppression of apoptosis

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机构： [a]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China [b]Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China

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关键词： Caloric restriction Learning ability Apoptosis Ageing

摘要：

Caloric restriction (CR) is the most reliable intervention to extend lifespan and prevent age-related disorders in various species from yeast to rodents. However, the underlying mechanisms have not yet been clearly defined. Therefore, we aimed to identify the underlying mechanisms of long-term CR on age-related learning impairment in C57/BL mice. Thirty six-week-old male C57/BL mice were randomly divided into three groups: normal control group (NC group, n = 10), high energy group (HE group, n = 10), and CR group (n = 10). After 10 months, the Morris water maze test was performed to monitor learning abilities. Western blotting, immunohistochemistry and real-time polymerase chain reaction were used to monitor changes in protein and mRNA levels associated with apoptosis-related proteins in the hippocampus. The average escape latency was lower in the CR group compared with the NC group, and the average time taken to first cross the platform in the CR group was significantly shorter than the HE group. Both Bcl-2 protein and mRNA expression levels in the CR group were significantly higher than those of the NC group and HE group. The expression of Bax, Caspase-3 and PARP protein in the CR group was significantly lower than the NC group. Our findings demonstrate that long-term CR may prevent age-related learning impairments via suppressing apoptosis in mice. (C) 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区行为科学 3 区神经科学

最新[2023]版：

大类 | 3 区心理学

小类 | 4 区行为科学 4 区神经科学

JCR分区：

出版当年[2014]版：

Q2 NEUROSCIENCES Q2 BEHAVIORAL SCIENCES

最新[2023]版：

Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子： 2.6 最新[2023版] 2.8 最新五年平均 3.028 出版当年[2014版] 3.298 出版当年五年平均 3.391 出版前一年[2013版] 3.002 出版后一年[2015版]

第一作者：

第一作者机构： [a]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China [b]Central Laboratory, Xuan Wu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China

通讯作者：

通讯机构： [*1]Central Laboratory Xuan Wu Hospital, Capital MedicalUniversity #45 Changchun Street, Xicheng District, Beijing 100053, China.

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