机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[2]Department of Neurology, The First Hospital of Harbin, Harbin, China.
Background: Despite being an important cause of death and functional disability, acute cerebral infarction (ACI) lacks accurate and easy tools to predict the outcome of patients beyond clinical variables such as age and stroke severity. Methods: To investigate if plasma D-dimer level can be used as such a prognostic biomarker for ACI, so as to better guide patients' management, we studied the association between plasma D-dimer and the functional recovery of 1173 ACI patients. The patients were divided into 2 groups according to modified Rankin Scale (mRS) scores or National Institutes of Health Stroke Scale (NIHSS) scores evaluated on the 30th day after onset. Results: We observed that plasma D-dimer level correlated significantly with the prognosis of ACI evaluated based on both mRS scores (389.68 +/- 32.06 mu g/L for poor prognosis versus 377.70 +/- 32.68 mu g/L for good prognosis, P < .001) and NIHSS scores (387.01 +/- 30.60 mu g/L for poor prognosis versus 375.23 +/- 30.66 mu g/L for good prognosis, P < .01). Logistic analysis confirmed that higher D-dimer level was a risk factor for poor prognosis (mRS: odds ratio [OR], 1.604; 95% confidence interval [CI], 1.360-1.892; P < .001; NIHSS: OR, 1.733; 95% CI, 1.461-2.056; P < .01), after adjusted for age, gender, hypertension, diabetes, smoking, and hyperlipidemia. Conclusion: Our results show that plasma D-dimer level is a promising prognosis biomarker for ACI.
基金：
the Innovation Experts of Science and Technology Support Program Foundation of Harbin City Heilongjiang State (No. 2011RC2011QN003027).
第一作者机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China[2]Department of Neurology, The First Hospital of Harbin, Harbin, China.
通讯作者：
通讯机构：[*1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Jing Wang ,Ruizhuo Ning ,Yuping Wang .Plasma D-dimer Level, the Promising Prognostic Biomarker for the Acute Cerebral Infarction Patients[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2016,25(8):2011-2015.doi:10.1016/j.jstrokecerebrovasdis.2015.12.031.
APA：
Jing Wang,,Ruizhuo Ning,&Yuping Wang,.(2016).Plasma D-dimer Level, the Promising Prognostic Biomarker for the Acute Cerebral Infarction Patients.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,25,(8)
MLA：
Jing Wang,,et al."Plasma D-dimer Level, the Promising Prognostic Biomarker for the Acute Cerebral Infarction Patients".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 25..8(2016):2011-2015
