机构：[a]Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China,[b]School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia,[c]Genos Glycobiology Research Laboratory, Zagreb, Croatia,[d]Physical Examination Center, Xuanwu Hospital, Capital Medical University, Beijing, China,首都医科大学宣武医院[e]Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK.
As an important post-translation modifying process, glycosylation significantly affects the structure and function of immunoglobulin G (IgG) molecules and is essential in many steps of the inflammatory cascade. Studies have demonstrated the potential of using glycosylation features of IgG as a component of predictive biomarkers for chronological age in several European populations, whereas no study has been reported in Chinese. Herein, we report various patterns of changes in IgG glycosylation associated with age by analyzing IgG glycosylation in 701 community-based Han Chinese (244 males, 457 females; 23-68 years old). Eleven IgG glycans, including FA2B, A2G1, FA2[6]G1, FA2[3]G1, FA2[6]BG1, FA2[3]BG1, A2G2, A2BG2, FA2G2, FA2G2S1, and FA2G2S2, change considerably with age and specific combinations of these glycan features can explain 23.3% to 45.4% of the variance in chronological age in this population. This indicates that these combinations of glycan features provide more predictive information than other single markers of biological age such as telomere length. In addition, the clinical traits such as fasting plasma glucose and aspartate aminotransferase associated with biological age are strongly correlated with the combined glycan features. We conclude that IgG glycosylation appears to correlate with both chronological and biological ages, and thus its possible role in the aging process merits further study.
基金：
Australian National Health & Medical Research Council; National Natural Science Foundation of China [NHMRC-APP1112767-NSFC 81561128020, 81273170, 81370083, 81001281, 81373099, 81573215]; National "12th Five-Year" Plan for Science and Technology Support, China [2012BAI37B03]; Connecting Australia-Europe Science and Innovation Excellence (CAESIE-Priming); Chinese Scholarship Council [CSC-2015]; Importation and Development of High-Calibre Talents Project of Beijing Municipal Institutions [CITTCD201404185]; Beijing Higher Education Young Elite Teacher Project [YETP1671]; Beijing Nova Program [Z141107001814058]
第一作者机构：[a]Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China,[b]School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia,
通讯作者：
通讯机构：[*1]Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China[*2]Global Health and Genomics, School of Medical and Health Sciences, Edith Cowan University, WA 6027, Australia
推荐引用方式(GB/T 7714)：
Xinwei Yu,Youxin Wang ,Jasminka Kristic,et al.Profiling IgG N-glycans as potential biomarker of chronological and biological ages A community-based study in a Han Chinese population[J].MEDICINE.2016,95(28):e4112.doi:10.1097/MD.0000000000004112.
APA：
Xinwei Yu,Youxin Wang,,Jasminka Kristic,Jing Dong,,Xi Chu...&Wei Wang,.(2016).Profiling IgG N-glycans as potential biomarker of chronological and biological ages A community-based study in a Han Chinese population.MEDICINE,95,(28)
MLA：
Xinwei Yu,et al."Profiling IgG N-glycans as potential biomarker of chronological and biological ages A community-based study in a Han Chinese population".MEDICINE 95..28(2016):e4112
