Purpose: Insulin resistance plays a role in the development of dementia and hypertension. We investigated a possible relationship between cognitive impairment and insulin resistance in elderly Chinese patients with primary hypertension. Materials and Methods: One hundred and thirty-two hypertensive elderly patients (>60 years) were enrolled in this study, and assigned into either the cognitive impairment group (n=61) or the normal cognitive group (n=71). Gender, age, education, body mass index (BMI), waist hip ratio (WEIR), total cholesterol (TC), triglyceride (TG), C-reactive protein (CRP), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), creatinine (Cr), fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model of assessment for insulin resistance index (HOMA-IR), systolic blood pressure, diastolic blood pressure, smoking history, atherosclerosis and the proportion of uncontrolled hypertension were compared between the two groups. Multi-factorial logistic regression analysis was performed. Results: No significant differences were found in gender, age, TC, CRP, HDL-C, LDL-C, Cr, BP, smoking history, atherosclerosis and the proportion of uncontrolled hypertension between the two groups. The cognitive impairment group had lower education levels, and higher BMI, WHIR, TG, FPG, FINS, and HOMA-IR levels than the control group. Logistic regression analysis revealed the levels of education, BMI, WHR, and HOMA-IR as independent factors that predict cognitive impairment in patients. Conclusion: Our study demonstrates that poor education and increased BMI, WHR, and HOMA-IR are independent risk factors for cognitive impairment in elderly patients with hypertension. Insulin resistance plays an important role in the development of cognitive impairment in primary elderly hypertensive patients.
基金:
The Min-istry of Health Welfare Industry Special Fund (201002011), MOE (Ministry of Education in China) Project of Humani-ties and Social Sciences (12YJCZH146), and Beijing Mu-nicipal Health Bureau Research Fund (Jing 13-02).
第一作者机构:[1]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing, China
通讯作者:
通讯机构:[*]Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, #45 Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714):
Lina Ma ,Ming Feng ,Yuying Qian ,et al.Insulin Resistance Is an Important Risk Factor for Cognitive Impairment in Elderly Patients with Primary Hypertension[J].YONSEI MEDICAL JOURNAL.2015,56(1):89-94.doi:10.3349/ymj.2015.56.1.89.
APA:
Lina Ma,,Ming Feng,,Yuying Qian,,Wei Yang,,Jia Liu,...&Yun Li.(2015).Insulin Resistance Is an Important Risk Factor for Cognitive Impairment in Elderly Patients with Primary Hypertension.YONSEI MEDICAL JOURNAL,56,(1)
MLA:
Lina Ma,,et al."Insulin Resistance Is an Important Risk Factor for Cognitive Impairment in Elderly Patients with Primary Hypertension".YONSEI MEDICAL JOURNAL 56..1(2015):89-94