机构：[a]Department of Neurobiology Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院[b]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, Beijing, China[c]WinconTheraCells Biotechnologies Co, LTD, Nanning, Guangxi, China[d]Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, USA
Nonhuman primates (NHPs) are useful for the study of age-associated changes in the brain as a model that is biologically closely related to humans. For example, with age, all NHPs analyzed to date, develop beta-amyloid (A beta) plaques as seen in humans. Nevertheless, it is still unclear if NHPs have human-like age-associated changes in A beta and tau protein in cerebrospinal fluid. The present study was an attempt to specifically address these issues. Cerebrospinal fluid levels of A beta and phosphorylated tau were measured in 37 and 22 cynomolgus monkeys, respectively, with ages ranging from 4 to 22-year-old. The result from the present study revealed significant age-associated declines in A beta 42 levels but not in A beta 40 and phosphorylated tau levels. This finding appears to parallel changes seen with human aging, in which decreased levels of A beta 42 can be seen in normal older adults, and supporting that cynomolgus monkeys would be a useful model for studying age-related neurologic disorders associated with Alzheimer-like cerebral proteopathy. (C) 2014 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of China [31240043]; State High-Tech Development Plan of Ministry of Sciences and Technology of China [2012AA020703, 2012AA02A514]; National Basic Research Development Program of China [2011CB504101]; Department of Anatomy and Neurobiology, University of Kentucky College of Medicine
第一作者机构：[a]Department of Neurobiology Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China[b]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing, Beijing, China
通讯作者：
通讯机构：[*1]Department of Anatomy and Neurobiology, University of Kentucky, Chandler Medical Center, 48Whitney-Hendrickson Bldg, Lexington, KY 40536-0098, USA.
推荐引用方式(GB/T 7714)：
Feng Yue,Chunling Lu,Yi Ai,et al.Age-associated changes of cerebrospinal fluid amyloid-beta and tau in cynomolgus monkeys[J].NEUROBIOLOGY OF AGING.2014,35(7):1656-1659.doi:10.1016/j.neurobiolaging.2014.01.139.
APA：
Feng Yue,Chunling Lu,Yi Ai,Piu Chan&Zhiming Zhang.(2014).Age-associated changes of cerebrospinal fluid amyloid-beta and tau in cynomolgus monkeys.NEUROBIOLOGY OF AGING,35,(7)
MLA：
Feng Yue,et al."Age-associated changes of cerebrospinal fluid amyloid-beta and tau in cynomolgus monkeys".NEUROBIOLOGY OF AGING 35..7(2014):1656-1659
