机构：[1]The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia[2]Division of Epidemiology and Community Health, School of Public Health University of Minnesota, Minneapolis, MN, USA[3]Chinese University of Hong Kong, Hong Kong, China[4]Department of Community Medicine, The University of Hong Kong, Hong Kong, China[5]Department of Health Science, Shiga University of Medical Science, Shiga, Japan[6]Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[7]Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands[8]Institute for Health Promotion,Graduate School of Public Health, Yonsei University, Seoul, Korea[9]Cancer Epidemiology Centre, Cancer Council Victoria,Melbourne, Vic., Australia[10]Centre for MEGA Epidemiology, School of Public Health, University of Melbourne, Melbourne, Vic., Australia[11]Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic., Australia[12]Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA
BackgroundThe risk of stroke is high in men among both Asian and non-Asian populations, despite differences in risk factor profiles; whether risk factors act similarly in these populations is unknown. AimTo study the associations between five major risk factors and stroke risk, comparing Asian with non-Asian men. MethodsWe obtained data from the Asia Pacific Cohort Studies Collaboration, a pooled analysis of individual participant data from 44 studies involving 386411 men with 9<bold>4</bold> years follow-up. Using cohorts from Asia and Australia/New Zealand Cox models were fitted to estimate risk factor associations for ischemic and haemorrhagic stroke. ResultsWe identified significant, positive associations between all five risk factors and risk of ischemic stroke. The associations between body mass index, smoking, and diabetes with ischemic stroke were comparable for men from Asia and Australia/New Zealand. The association between systolic blood pressure and ischemic stroke was stronger for Asian than Australia/New Zealand cohorts, whereas the reverse was true for total cholesterol. For haemorrhagic stroke, only systolic blood pressure and smoking were associated with increased risk, although the relationship with systolic blood pressure was significantly stronger for men from Asia than Australia/New Zealand (P-interaction=0<bold>03</bold>), whereas the reverse was true for smoking (P-interaction=0<bold>001</bold>). There was an inverse trend of total cholesterol with haemorrhagic stroke, significant only for Asian men. ConclusionsMen from the Asia-Pacific region share common risk factors for stroke. Strategies aimed at lowering population levels of systolic blood pressure, total cholesterol, body mass index, smoking, and diabetes are likely to be beneficial in reducing stroke risk, particularly for ischemic stroke, across the region.
第一作者机构：[1]The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia
通讯作者：
通讯机构：[*1]Division of Epidemiology & Community Health, University of Minnesota, 1300 S 2nd Street, Suite 300, Minneapolis, MN 55454, USA.
推荐引用方式(GB/T 7714)：
Karice K. Hyun,Rachel R. Huxley,Hisatomi Arima,et al.A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration[J].INTERNATIONAL JOURNAL OF STROKE.2013,8(8):606-611.doi:10.1111/ijs.12166.
APA：
Karice K. Hyun,Rachel R. Huxley,Hisatomi Arima,Jean Woo,Tai Hing Lam...&Mark Woodward.(2013).A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration.INTERNATIONAL JOURNAL OF STROKE,8,(8)
MLA：
Karice K. Hyun,et al."A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration".INTERNATIONAL JOURNAL OF STROKE 8..8(2013):606-611
