机构：[a]Departments of Radiology, Xuanwu Hospital, Capital Medical University,Beijing , PR China放射科首都医科大学宣武医院[b]Departments of Neurology, Xuanwu Hospital, Capital Medical University, Beijing , PR China神经内科首都医科大学宣武医院[c]Departments of Beijing Key Laboratory of MRI and Brain Informatics, Beijing , PR China[d]Department of Medicine, University of Melbourne, Parkville, Vic. , Australia
Aims: To assess the demographic, clinical and spinal cord MRI characteristics of clinically definite neuromyelitis optica (NMO) patients for association with anti-aquaporin-4 (AQP4) antibody positivity in Chinese patients. Methods: We recruited 72 consecutive patients with NMO. The clinical assessments, sera and spinal MRI scans were obtained within 1 week after the onset of symptoms of acute myelitis. The statistical significance of potential differences in demographic, clinical and spinal MRI lesion characteristics between the two groups (anti-AQP4 antibody positive vs. negative) was determined using the two-sample t test or Fisher's exact test. Results: Forty-nine patients (49/72, 68.1%) were anti-AQP4 antibody positive and 23 patients (23/72, 31.9%) were anti-AQP4 antibody negative. The only characteristic that was significantly different between the groups was the presence of an enhancing spinal cord lesion (p < 0.001). Conclusion:We found a strong association between serum anti-AQP4 antibody positivity and lesional gadolinium enhancement in patients with clinically definite NMO. These findings support prior evidence that anti-AQP4 antibody could be pathogenic in NMO lesion development. Copyright (C) 2013 S. Karger AG, Basel
基金：
National Natural Science Foundation of China (No. 81101038, 30930029)
Beijing Natural Science Foundation (No. 7133244)
第一作者机构：[a]Departments of Radiology, Xuanwu Hospital, Capital Medical University,Beijing , PR China[c]Departments of Beijing Key Laboratory of MRI and Brain Informatics, Beijing , PR China
通讯作者：
通讯机构：[*1]Department of Radiology, Xuanwu Hospital, Capital Medical University ,Beijing 100053 (PR China)
推荐引用方式(GB/T 7714)：
Yaou Liu,Yue Han,Yunyun Duan,et al.Anti-Aquaporin-4 Antibody Positivity in Neuromyelitis Optica Is Associated with Lesion Activity[J].EUROPEAN NEUROLOGY.2013,70(1-2):113-116.doi:10.1159/000352034.
APA：
Yaou Liu,Yue Han,Yunyun Duan,Jing Huang,Zhuoqiong Ren...&Kuncheng Li.(2013).Anti-Aquaporin-4 Antibody Positivity in Neuromyelitis Optica Is Associated with Lesion Activity.EUROPEAN NEUROLOGY,70,(1-2)
MLA：
Yaou Liu,et al."Anti-Aquaporin-4 Antibody Positivity in Neuromyelitis Optica Is Associated with Lesion Activity".EUROPEAN NEUROLOGY 70..1-2(2013):113-116
