机构：[a]Department of Neurology,University of L¨ubeck, L¨ubeck 23538,Germany[b]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,China神经外科首都医科大学宣武医院[c]Dept. of Neurology,Medical School Hannover,Germany[d]Dept. of Neurology,Medical University Sofia,Bulgaria[e]International Neuroscience Institute,Hannover,Germany
Parkinson's disease has been found to impair comprehension of complex sentences. Here we follow up on earlier findings that sentences describing two successive events in the form of "Before B, A" are understood worse by Parkinson patients than sentences in the form of "After A, B". Before-initial sentences express events in an order inconsistent with their actual order of occurrence and therefore require additional computations during comprehension. In a behavioral study we tested whether 28 German Parkinson patients reading 'before'- and 'after'-initial sentences correctly understood the sequence of events. A second functional magnetic resonance imaging study investigated 16 different patients who read sentences while in the scanner. The behavioral study revealed that 'before' sentences were misunderstood with regard to the temporal sequence of events in 53% (controls 6.5%). The imaging study demonstrated a functional network of the caudate nucleus, middle frontal gyrus, medial superior frontal gyrus, parietal lobule and inferior temporal gyrus. This network was dynamically modulated for 'before' compared to 'after' sentences in healthy controls but not in Parkinson patients. The current results suggest that the additional computations required for 'before' sentences are supported by a network with the caudate nucleus as a central element. This network was compromised in Parkinson patients. We propose that dysfunction of the caudate nucleus networks underlies Parkinson patients' difficulty in dealing with complex sentence structures. (C) 2012 Elsevier Ltd. All rights reserved.
基金：
Deutsche Forschungsgemeinschaft (DFG, SFB 779, TP A5)
the GermanFederal Department of Research BMBF,
the Center for Beha-vioral Brain Science Magdeburg
the Peter-Max-Müller Foundation
the European Federation of NeurologicalSocieties
第一作者机构：[a]Department of Neurology,University of L¨ubeck, L¨ubeck 23538,Germany[b]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing,China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurology,University of L¨ubeck, L¨ubeck 23538,Germany
推荐引用方式(GB/T 7714)：
Zheng Ye,MariaMilenkova,BahramMohammadi,et al.Impaired comprehension of temporal connectives in Parkinson's disease-A neuroimaging study[J].NEUROPSYCHOLOGIA.2012,50(8):1794-1800.doi:10.1016/j.neuropsychologia.2012.04.004.
APA：
Zheng Ye,MariaMilenkova,BahramMohammadi,KatjaKollewe,ChristophSchrader...&ThomasF.M¨ unte.(2012).Impaired comprehension of temporal connectives in Parkinson's disease-A neuroimaging study.NEUROPSYCHOLOGIA,50,(8)
MLA：
Zheng Ye,et al."Impaired comprehension of temporal connectives in Parkinson's disease-A neuroimaging study".NEUROPSYCHOLOGIA 50..8(2012):1794-1800
