机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University,神经内科首都医科大学宣武医院[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing , PR China[c]Department of Computer Science, University of Otago, Dunedin , New Zealand
Background: Studies on the associations between sex hormones and multiple neuropsychiatric symptoms of Alzheimer's disease (AD) are lacking. Apolipoprotein E (APOE) epsilon 4 status may modify the effects of sex hormones on neuropsychiatric symptoms. Methods: A total of 86 male and 87 female AD patients participated in the present study. The adjusted associations between symptoms on the Neuropsychiatric Inventory and serum levels of estradiol (total, bioavailable) and testosterone (total, bioavailable) were analyzed. Results: Agitation/aggression was negatively associated with quartiles of bioavailable estradiol among male patients, and positively associated with testosterone levels among female patients. The modifying effects of APOE genotype only existed in female patients. Those females with higher levels of estradiol and the epsilon 4 allele had higher odds of agitation/aggression. Furthermore, the testosterone x APOE epsilon 4 status interaction was positively associated with hallucinations in female patients. Conclusion: There were sex-specific effects of sex hormones on agitation/aggression in AD. Sex hormones and APOE epsilon 4 status synergistically influence some neuropsychiatric symptoms among female but not male AD patients. Copyright (C) 2012 S. Karger AG, Basel
基金：
National Key Technology R&D Program in the Eleventh Five-year Plan Period (2006BAI02B01)
the key project of the National Natural Science Foundation of China (30830045)
the National High Technology Research and Development Program 863 (2006AA02A408)
the National Science and Technology Major Projects for ‘Major New Drugs Innovation and Development’ in the Twelfth Five-year Plan Period (2011ZX09307-001-02)
the key project of Science and Technology Plan of Beijing Municipal Education Commission(KZ201010025023 and KZ200910025005)
the major project of Science and Technology Plan of Beijing Municipal Science and Technology Commission (SCW 2011-10)
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University,[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing , PR China
通讯作者：
通讯机构：[*1]Department of Neurology ,Xuan Wu Hospital of the Capital Medical University ,45 Changchun Street, Beijing 100053 (PR China)
推荐引用方式(GB/T 7714)：
Yi Xing,Wei Qin,Fang Li,et al.Apolipoprotein E epsilon 4 Status Modifies the Effects of Sex Hormones on Neuropsychiatric Symptoms of Alzheimer's Disease[J].DEMENTIA AND GERIATRIC COGNITIVE DISORDERS.2012,33(1):35-42.doi:10.1159/000336600.
APA：
Yi Xing,Wei Qin,Fang Li,Xiang-Fei Jia&Jianping Jia.(2012).Apolipoprotein E epsilon 4 Status Modifies the Effects of Sex Hormones on Neuropsychiatric Symptoms of Alzheimer's Disease.DEMENTIA AND GERIATRIC COGNITIVE DISORDERS,33,(1)
MLA：
Yi Xing,et al."Apolipoprotein E epsilon 4 Status Modifies the Effects of Sex Hormones on Neuropsychiatric Symptoms of Alzheimer's Disease".DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 33..1(2012):35-42
