机构：[a]LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China[b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China[c]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, PR China放射科首都医科大学宣武医院[d]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China
Twin studies have indicated a common genetic origin for intelligence and for variations in brain morphology. Our previous diffusion tensor imaging studies found an association between intelligence and white matter integrity of specific brain regions or tracts. However, specific genetic determinants of the white matter integrity of these brain regions and tracts are still unclear. In this study, we assess whether and how catechol-O-methyltransferase (COMT) gene polymorphisms affect brain white matter integrity. We genotyped twelve single nucleotide polymorphisms (SNPs) within the COMT gene and performed haplotype analyses on data from 79 healthy subjects. Our subjects had the same three major COMT haplotypes (termed the HPS, APS and ILPS haplotypes) as previous studies have reported as regulating significantly different levels of enzymatic activity and dopamine. We used the mean fractional anisotropy (FA) values from four regions and five tracts of interest to assess the effect of COMT polymorphisms, including the well-studied val158met SNP and the three main haplotypes that we had identified, on intelligence-related white matter integrity. We identified an association between the mean FA values of two regions in the bilateral prefrontal lobes and the COMT haplotypes, rather than between them and val158met. The haplotype-FA value associations modulated nonlinearly and fit an inverted U-model. Our findings suggest that COMT haplotypes can nonlinearly modulate the intelligence-related white matter integrity of the prefrontal lobes by more significantly influencing prefrontal dopamine variations than does val158met. (C) 2009 Elsevier Inc. All rights reserved.
基金：
the Natural Science Foundation of China, Grant Nos. 30730035, the National Key Basic Research and Development Program (973), Grant No. 2007CB512300,
the External Cooperation Program of the Chinese Academy of Sciences, Grant No. GJHZ200826, and the Program for New Century Excellent Talents in University, No. NCET-07-0568.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2009]版：
大类|2 区医学
小类|1 区神经成像1 区核医学2 区神经科学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2008]版：
Q1NEUROSCIENCESQ1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China
共同第一作者：
通讯作者：
通讯机构：[a]LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China
推荐引用方式(GB/T 7714)：
Bing Liu,Jun Li,Chunshui Yu,et al.Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity[J].NEUROIMAGE.2010,50(1):243-249.doi:10.1016/j.neuroimage.2009.12.020.
APA：
Bing Liu,Jun Li,Chunshui Yu,Yonghui Li,Yong Liu...&Tianzi Jiang.(2010).Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity.NEUROIMAGE,50,(1)
MLA：
Bing Liu,et al."Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity".NEUROIMAGE 50..1(2010):243-249
医学